Human Amyloid beta (aa1-42) Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 31. Show All 31 Publications. Collapse Publications.

Publications using DAB142	Applications	Species
Kang, D;Koh, S;Kim, T;Bressel, E;Kim, D; Circuit Training Improves the Levels of ?-Amyloid and Brain-Derived Neurotrophic Factor Related to Cognitive Impairment Risk Factors in Obese Elderly Korean Women Journal of clinical medicine 2024-01-30 [PMID: 38337492] (Human)		Human
Yeapuri, P;Machhi, J;Lu, Y;Abdelmoaty, MM;Kadry, R;Patel, M;Bhattarai, S;Lu, E;Namminga, KL;Olson, KE;Foster, EG;Mosley, RL;Gendelman, HE; Amyloid-? specific regulatory T cells attenuate Alzheimer's disease pathobiology in APP/PS1 mice Molecular neurodegeneration 2023-12-18 [PMID: 38111016] (Mouse)		Mouse
Oliveras-Cañellas, N;Castells-Nobau, A;de la Vega-Correa, L;Latorre-Luque, J;Motger-Albertí, A;Arnoriaga-Rodriguez, M;Garre-Olmo, J;Zapata-Tona, C;Coll-Martínez, C;Ramió-Torrentà, L;Moreno-Navarrete, JM;Puig, J;Villarroya, F;Ramos, R;Casadó-Anguera, V;Martín-García, E;Maldonado, R;Mayneris-Perxachs, J;Fernández-Real, JM; Adipose tissue coregulates cognitive function Science advances 2023-08-11 [PMID: 37566655]
Ge, J;Xue, Z;Shu, S;Yu, L;Qin, R;Tao, W;Liu, P;Dong, X;Lan, Z;Bao, X;Ye, L;Xu, Y;Zhu, X; MiR-431 attenuates synaptic plasticity and memory deficits in APPswe/PS1dE9 mice JCI insight 2023-05-16 [PMID: 37192007] (Mouse)		Mouse
Steinke, I;Govindarajulu, M;Pinky, PD;Bloemer, J;Yoo, S;Ward, T;Schaedig, T;Young, T;Wibowo, FS;Suppiramaniam, V;Amin, RH; Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer's Disease Cells 2023-04-08 [PMID: 37190025] (Mouse)		Mouse
H Liu, R Jiao, L Wang, F Feng, X Zhao, J Yang Machine-learning-based analysis of the sensitivity and specificity on lipid-lowering effect of one-month-administered statins Medicine, 2023-03-03;102(9):e33139. 2023-03-03 [PMID: 36862920] (Human)		Human
A Verma, G Azhar, X Zhang, P Patyal, G Kc, S Sharma, Y Che, JY Wei P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress International Journal of Molecular Sciences, 2023-01-04;24(2):. 2023-01-04 [PMID: 36674463] (Human)		Human
S Kumar, S Budhathoki, CB Oliveira, AD Kahle, OY Calhan, JR Lukens, CD Deppmann Role of the Caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Abeta-induced NLRP3 inflammasome activation JCI Insight, 2023-02-08;0(0):. 2023-02-08 [PMID: 36602874] (Mouse)		Mouse
H Jäntti, M Oksanen, P Kettunen, S Manta, L Mouledous, H Koivisto, J Ruuth, K Trontti, H Dhungana, M Keuters, I Weert, M Koskuvi, I Hovatta, AM Linden, C Rampon, T Malm, H Tanila, J Koistinaho, T Rolova Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice Cells, 2022-12-18;11(24):. 2022-12-18 [PMID: 36552881] (Human)		Human
J Diao, X Chen, P Mou, X Ma, R Wei Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts Investigative Ophthalmology & Visual Science, 2022-09-01;63(10):6. 2022-09-01 [PMID: 36094643] (Human)		Human
P Namchaiw, P Bunreangsr, P Eiamcharoe, S Eiamboonse, R P Poo-Arpo An in vitro workflow of neuron-laden agarose-laminin hydrogel for studying small molecule-induced amyloidogenic condition PLoS ONE, 2022-08-26;17(8):e0273458. 2022-08-26 [PMID: 36026506] (Human)		Human
C Morsiani, MG Bacalini, S Collura, M Moreno-Vil, N Breusing, A Bürkle, T Grune, C Franceschi, M De Eguileo, M Capri Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome Mechanisms of Ageing and Development, 2022-06-30;206(0):111691. 2022-06-30 [PMID: 35780970] (Human)		Human
H Cao, C Zuo, Z Gu, Y Huang, Y Yang, L Zhu, Y Jiang, F Wang High frequency repetitive transcranial magnetic stimulation alleviates cognitive deficits in 3xTg-AD mice by modulating the PI3K/Akt/GLT-1 axis Redox Biology, 2022-05-30;54(0):102354. 2022-05-30 [PMID: 35660628] (Mouse)		Mouse
C He, Q Li, Y Cui, P Gao, W Shu, Q Zhou, L Wang, L Li, Z Lu, Y Zhao, H Ma, X Chen, H Jia, H Zheng, G Yang, D Liu, M Tepel, Z Zhu Recurrent moderate hypoglycemia accelerates the progression of cognitive deficits through impairment of TRPC6/GLUT3 pathway in diabetic APP/PS1 mice JCI Insight, 2022-03-08;0(0):. 2022-03-08 [PMID: 35077394] (Mouse)		Mouse
JJ Tang, LF Huang, JL Deng, YM Wang, C Guo, XN Peng, Z Liu, JM Gao Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model Redox Biology, 2022-01-08;50(0):102229. 2022-01-08 [PMID: 35026701] (Transgenic Mouse)		Transgenic Mouse
SH Kim, EH Lee, HJ Kim, AR Kim, YE Kim, JH Lee, MY Yoon, SH Koh Development of a Low-Molecular-Weight Abeta42 Detection System Using a Enzyme-Linked Peptide Assay Biomolecules, 2021-12-02;11(12):. 2021-12-02 [PMID: 34944462] (Human)		Human
B Bhargavan, SM Woollard, JE McMillan, GD Kanmogne CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice Molecular Neurodegeneration, 2021-11-22;16(1):78. 2021-11-22 [PMID: 34809709] (Human)		Human
J Cheng, Y Dong, J Ma, R Pan, Y Liao, X Kong, X Li, S Li, P Chen, L Wang, Y Yu, Z Yuan Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology Science Advances, 2021-08-25;7(35):. 2021-08-25 [PMID: 34433553] (Mouse)		Mouse
H Wang, JA Kulas, C Wang, DM Holtzman, HA Ferris, SB Hansen Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol Proceedings of the National Academy of Sciences of the United States of America, 2021-08-17;118(33):. 2021-08-17 [PMID: 34385305] (Mouse)		Mouse
R Wiest, TS Weiss, L Danielyan, C Buechler Serum Amyloid Beta42 Is Not Eliminated by the Cirrhotic Liver: A Pilot Study Journal of Clinical Medicine, 2021-06-17;10(12):. 2021-06-17 [PMID: 34204545] (Human)		Human
A Roth, F Gärtner, K Mayer, J Beyrle, I König, U Knippschil, J Bischof CK1delta-Derived Peptides as Novel Tools Inhibiting the Interactions between CK1delta and APP695 to Modulate the Pathogenic Metabolism of APP International Journal of Molecular Sciences, 2021-06-15;22(12):. 2021-06-15 [PMID: 34203978] (Human)		Human
M Wang, LR Feng, ZL Li, KG Ma, KW Chang, XL Chen, PB Yang, SF Ji, YB Ma, H Han, JB Ruganzua, WN Yang, YH Qian Thymosin &beta4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-&kappaB signaling axis in APP/PS1 mice Journal of Neuroinflammation, 2021-06-28;18(1):146. 2021-06-28 [PMID: 34183019] (Mouse)		Mouse
N Brookhouse, S Raman, C Frisch, G Srinivasan, DA Brafman APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease Molecular Psychiatry, 2021-04-09;0(0):. 2021-04-09 [PMID: 33837271] (Human)		Human
K Richter, R Ogiemwonyi, S Wilker, AI Chaveiro, A Agné, M Hecker, M Reichert, AL Amati, KD Schlüter, I Manzini, G Schmalzing, JM McIntosh, W Padberg, V Grau, A Hecker Amyloid Beta Peptide (A&beta1-42) Reverses the Cholinergic Control of Monocytic IL-1&beta Release J Clin Med, 2020-09-07;9(9):. 2020-09-07 [PMID: 32906646] (Human)		Human
A Picca, D Ronconi, HJ Coelho-Jun, R Calvani, F Marini, A Biancolill, J Gervasoni, A Primiano, C Pais, E Meloni, D Fusco, MR Lo Monaco, R Bernabei, MC Cipriani, E Marzetti, R Liperoti The "develOpment of metabolic and functional markers of Dementia IN Older people" (ODINO) Study: Rationale, Design and Methods J Pers Med, 2020-04-09;10(2):. 2020-04-09 [PMID: 32283734] (Human)		Human
Z Gong, J Huang, B Xu, Z Ou, L Zhang, X Lin, X Ye, X Kong, D Long, X Sun, X He, L Xu, Q Li, A Xuan Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice J Neuroinflammation, 2019-03-14;16(1):62. 2019-03-14 [PMID: 30871577] (Mouse)		Mouse
C Huang, H Chu, Y Ma, Z Zhou, C Dai, X Huang, L Fang, Q Ao, D Huang The neuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer's disease Brain Stimul, 2018-08-27;0(0):. 2018-08-27 [PMID: 30181106] (Mouse)		Mouse
T Suganuma, SK Swanson, M Gogol, TJ Garrett, J Conkright-, L Florens, MP Washburn, JL Workman MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism Cell Rep, 2018-08-07;24(6):1585-1596. 2018-08-07 [PMID: 30089268] (Human)		Human
P Liu, X Chen, H Zhou, L Wang, Z Zhang, X Ren, F Zhu, Y Guo, X Huang, J Liu, PS Spencer, X Yang The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro Oxid Med Cell Longev, 2018-07-02;2018(0):2025914. 2018-07-02 [PMID: 30057671] (Mouse)		Mouse
X Zhu, S Wang, L Yu, J Jin, X Ye, Y Liu, Y Xu HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease Aging Cell, 2017-08-03;0(0):. 2017-08-03 [PMID: 28771976] (Mouse)		Mouse
Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI Sci Rep, 2016-11-23;6(0):37486. 2016-11-23 [PMID: 27876835] (Human)		Human
Show All 31 Publications. Collapse Publications.

Array DAB142

• beta Amyloid Antibodies
• beta Amyloid ELISAs