hnRNP M1-M4 Antibody (1D8)

RNA-binding proteins of mammalian hnRNP (heterogeneous nuclear ribonucleo protein) family represents a group of over 20 distinct evolutionary conserved proteins which share a capability to bind pre-mRNA/mRNA, and also binds to specific RNA motifs with high-affinity. They exhibit huge functional diversity and implicates in almost every step in mRNA's life cycle (from transcription and processing to transport and translation). HnRNP M is an abundant protein containing three RNA recognition motifs (RRM), a glycine/methionine-rich region and a methionine/arginine-rich repeat motif. It has four protein variants, hnRNP M1-4, ranging in molecular size from 68 to 72 kD which corresponds to spliced isoforms and/or posttranslationally modified forms. hnRNP M is a nucleolar protein and has been Identified in the spliceosome C complex. It acts as a pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro, and is involved in splicing. hnRNP M acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and TNF-alpha cytokines.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Bovine, Rabbit.

We have publications tested in 5 applications: Func, ICC/IF, IP, PLA, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB200-314	Applications	Species
Victoria O. Shender, Ksenia S. Anufrieva, Polina V. Shnaider, Georgij P. Arapidi, Marat S. Pavlyukov, Olga M. Ivanova, Irina K. Malyants, Grigory A. Stepanov, Evgenii Zhuravlev, Rustam H. Ziganshin, Ivan O. Butenko, Olga N. Bukato, Ksenia M. Klimina, Vladimir A. Veselovsky, Tatiana V. Grigorieva, Sergey Y. Malanin, Olga I. Aleshikova, Andrey V. Slonov, Nataliya A. Babaeva, Lev A. Ashrafyan, Elena Khomyakova, Evgeniy G. Evtushenko, Maria M. Lukina, Zixiang Wang, Artemiy S. Silantiev, Anna A. Nushtaeva, Daria D. Kharlampieva, Vassili N. Lazarev, Arseniy I. Lashkin, Lorine K. Arzumanyan, Irina Yu. Petrushanko, Alexander A. Makarov, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova, Vadim M. Govorun Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells Nature Communications 2024-06-19 [PMID: 38898005]
Andrey Damianov, Chia-Ho Lin, Jeffrey Huang, Lin Zhou, Yasaman Jami-Alahmadi, Parham Peyda, James Wohlschlegel, Douglas L Black The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin. Molecular cell 2024-04-22 [PMID: 38537639]
Lleres D, Denegri M, Biggiogera M, Ajuh P, Lamond AI. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. EMBO Rep;11(6):445-51. 2010-06-01 [PMID: 20467437] (WB, Human)	WB	Human
Vassileva MT, Matunis MJ. SUMO modification of heterogeneous nuclear ribonucleoproteins. Mol Cell Biol;24(9):3623-32. 2004-05-01 [PMID: 15082759] (IP, Human)	IP	Human
Kafasla P, Patrinou-Georgoula M, Guialis A. The 72/74-kDa polypeptides of the 70-110 S large heterogeneous nuclear ribonucleoprotein complex (LH-nRNP) represent a discrete subset of the hnRNP M protein family. Biochem J;350 Pt 2:495-503. 2000-09-01 [PMID: 10947964] (WB, Rat)	WB	Rat
Datar KV, Dreyfuss G, Swanson MS. The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. Nucleic Acids Res;21(3):439-46. 1993 Feb 11. [PMID: 8441656] (WB, Human, Rabbit, Mouse)	WB	Human, Rabbit, Mouse
Hehman GL, Hauswirth WW. DNA helicase from mammalian mitochondria. Proc Natl Acad Sci U S A;89(18):8562-6. 1992-09-15 [PMID: 1326759] (WB, Bovine)	WB	Bovine
Birladeanu A, Rogalska M, Potiri M, Papadaki V Nuclear IQGAP1 promotes gastric cancer cell growth by altering the splicing of a cell-cycle regulon in co-operation with hnRNPM bioRxiv 2020-01-01 (Func, Mouse)	Func	Mouse
Birladeanu A, Rogalska M, Potiri M et al. The IQGAP1-hnRNPM interaction links tumour-promoting alternative splicing to heat-induced signals bioRxiv 2020-05-14 (ICC/IF, PLA, Human)	ICC/IF, PLA	Human
Birladeanu A, Rogalska M, Potiri M, Papadaki V The Scaffold Protein IQGAP1 Links Heat-Induced Stress Signals to Alternative Splicing Regulation in Gastric Cancer Cells Oncogene 2021-07-23 [PMID: 34294847]
Zhao Q, Liu J, Deng H et al. Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output Cell 2020-09-05 [PMID: 32931733] (WB, Mouse, Human)	WB	Mouse, Human
Timchenko L T, Miller J W et al. Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res 1996-11-15 [PMID: 8948631] (WB, Mouse)	WB	Mouse
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Panagiota Kafasla	WB	Mouse	07/09/2013	View Summary Application Western Blot Sample Tested Mouse total lysate, macrophages Species Mouse Lot A

Array NB200-314

• hnRNP M1-M4 Antibodies
• hnRNP M1-M4 Protein