HIP1 Antibody (1B11)

One of the four subunits of the histone regulatory complex A, HIP1 is an anti-apoptosis protein in the brain. HIP1 (Huntingtin-interacting protein 1) protects normal neurological tissue from erroneous inflammatory and apoptotic events by linking the actin cytoskeleton and clathrin-mediated endocytosis machinery. It is important in the generation of clathrin coated vesicles in the neuron. However, if deletion of HIP1 occurs, neurological disease is initiated and is correlated to epilepsy, learning disabilities, spinal and testicular defects, hematopoietic issues, and other neurobehavioral abnormalities such as Huntington's disease. HIP1 also interacts with the Hedgehog signaling pathway, and is important in regulating the abundance and scope of Hedgehog signaling.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Bacteria.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 7 of 7.

Publications using NB300-204	Applications	Species
Choudhury KR, Raychaudhuri S, Bhattacharyya NP. Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death. PLoS One. 2012-12-10 [PMID: 23272104] (IP, Human)	IP	Human
Datta M, Choudhury A, Lahiri A, Bhattacharyya NP. Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation. BMC Genomics;12(1):463. 2011-09-26 [PMID: 21943362]
Datta M, Bhattacharyya NP. Regulation of RE1 Protein Silencing Transcription Factor (REST) Expression by HIP1 Protein Interactor (HIPPI). J Biol Chem;286(39):33759-33769. 2011-09-30 [PMID: 21832040] (WB, Human)	WB	Human
Banerjee M, Datta M, Majumder P et al. Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1. Nucleic Acids Res. 2010-01-01 [PMID: 19934260] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Mills IG et al. Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J Cell Biol; 70: 191-200. 2005-01-01 [PMID: 16027218] (WB, Bacteria)	WB	Bacteria
Rao, DS et al. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J Clin Invest;110(3):351-60. 2002-08-01 [PMID: 12163454] (WB, Human, Mouse)	WB	Human, Mouse
Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS. Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Mol Cell Biol;21(22):7796-806. 2001-11-01 [PMID: 11604514] (ICC/IF, Human)	ICC/IF	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	ICC	Human	11/11/2021	View Summary Application Immunocytochemistry Sample Tested Human pluripotent embryonal carcinoma cells Species Human Lot 1B11

Array NB300-204

• HIP1 Antibodies
• HIP1 Proteins