HHEX Antibody (2018B) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Hematopoietically-expressed homeobox protein (HHEX), also known as HEX, PRH and PRHX, is a 35-40 kDa member of the Homeobox family of transcription factors.  Family members are distinguished by an evolutionarily conserved DNA-binding homeodomain of 60 amino acids (aa), which for HHEX spans aa 137-196.  Human HHEX was initially isolated from hematopoietic tissue, and is present in several hematopoietic progenitors, where its expression is down-regulated during terminal cell differentiation.  HHEX is also expressed in the anterior visceral endoderm during early mouse development, and in some adult tissues of endodermal origin, including liver, lung and thyroid.  HHEX knockout in mice is embryonic lethal, with impaired forebrain, liver and thyroid development.  Human HHEX is 270 aa in length, and over aa 111-270, shares 93% and 95% identity with mouse and rat HHEX, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ChIP, ICC, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB83771	Applications	Species
Ito, R;Kimura, A;Hirose, Y;Hatano, Y;Mima, A;Mae, SI;Keidai, Y;Nakamura, T;Fujikura, J;Nishi, Y;Ohta, A;Toyoda, T;Inagaki, N;Osafune, K; Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model Scientific reports 2023-05-29 [PMID: 37248264] (Western Blot, Human)	Western Blot	Human
YF Wong, Y Kumar, M Proks, JAR Herrera, MM Rothová, RS Monteiro, S Pozzi, RE Jennings, NA Hanley, WA Bickmore, JM Brickman Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation Nature Cell Biology, 2023-01-23;0(0):. 2023-01-23 [PMID: 36690849] (ChIP, Human)	ChIP	Human
D Yang, H Cho, Z Tayyebi, A Shukla, R Luo, G Dixon, V Ursu, S Stransky, DM Tremmel, SD Sackett, R Koche, SJ Kaplan, QV Li, J Park, Z Zhu, BP Rosen, J Pulecio, ZD Shi, Y Bram, RE Schwartz, JS Odorico, S Sidoli, CV Wright, CS Leslie, D Huangfu CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction Nature Cell Biology, 2022-07-04;0(0):. 2022-07-04 [PMID: 35787684] (Western Blot, Human)	Western Blot	Human
J Zhao, P Lu, C Wan, Y Huang, M Cui, X Yang, Y Hu, Y Zheng, J Dong, M Wang, S Zhang, Z Liu, S Bian, X Wang, R Wang, S Ren, D Wang, Z Yao, G Chang, F Tang, XY Zhao Cell-fate transition and determination analysis of mouse male germ cells throughout development Nature Communications, 2021-11-25;12(1):6839. 2021-11-25 [PMID: 34824237] (Western Blot, Mouse)	Western Blot	Mouse
W Goh, S Scheer, JT Jackson, S Hediyeh-Za, RB Delconte, IS Schuster, CE Andoniou, J Rautela, MA Degli-Espo, MJ Davis, MP McCormack, SL Nutt, ND Huntington Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance Cell Rep, 2020-10-20;33(3):108285. 2020-10-20 [PMID: 33086067] (Western Blot, Mouse)	Western Blot	Mouse
RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development Cell Rep, 2019-04-16;27(3):708-718.e10. 2019-04-16 [PMID: 30995470] (ICC, Human)	ICC	Human

Array MAB83771

• HHEX Antibodies
• HHEX Lysate
• HHEX Proteins