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HDAC9 Antibody [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, Mu, Bv, Ca, Pm, Rt, Pm, Eq, Ma-Op, Pm-Or, RMSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 549

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HDAC9 Antibody [Janelia Fluor® 549] Summary

Immunogen
A portion of amino acids 100-150 of human HDAC-9 was used as the immunogen.
Predicted Species
Rat (100%), Equine (100%), Orangutan (100%), Chimpanzee (100%), Rhesus Macaque (100%), Opossum (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HDAC9
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for HDAC9 Antibody [Janelia Fluor® 549]

  • EC 3.5.1.98
  • HD7b
  • HD7HDAC
  • HD9
  • HDAC7
  • HDAC7B
  • HDAC7BDKFZp779K1053
  • HDAC9
  • HDRP
  • histone deacetylase 4/5-related protein
  • Histone deacetylase 7B
  • histone deacetylase 9
  • Histone deacetylase-related protein
  • KIAA0744
  • KIAA0744HDAC9B
  • MEF-2 interacting transcription repressor (MITR) protein
  • MEF2-interacting transcription repressor MITR
  • MITR
  • MITRHDAC9FL

Background

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol HDAC9