HDAC9 Products

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Bioinformatics

Entrez	9734 Human
Uniprot	AAI11736.1 Human NM_178423 Human NP_055522 Human NP_478056 Human NP_848512.1 Human Q9UKV0 Human
Product By Gene ID	9734
Alternate Names	EC 3.5.1.98 HD7b HD7HDAC HD9 HDAC7 HDAC7BDKFZp779K1053 HDRP histone deacetylase 4/5-related protein Histone deacetylase 7B histone deacetylase 9 Histone deacetylase-related protein KIAA0744HDAC9B MEF-2 interacting transcription repressor (MITR) protein MEF2-interacting transcription repressor MITR MITRHDAC9FL

Research Areas for HDAC9

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Epigenetics
Histone Deacetylases