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Granzyme K Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP2-49387] - Analysis in human tonsil and cerebral cortex tissues. Corresponding Granzyme K RNA-seq data are presented for the same ...read more
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP2-49387] - Staining of human spleen shows strong granular cytoplasmic positivity in cells in red pulp.
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP2-49387] - Staining of human tonsil shows high expression.
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP2-49387] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP2-49387] - Staining of human rectum shows weak granular cytoplasmic positivity in leukocytes.
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP2-49387] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

Granzyme K Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: KCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDS
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GZMK
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200-1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Granzyme K Recombinant Protein Antigen (NBP2-49387PEP)
Reviewed Applications
Read 1 Review rated 5
using
NBP2-49387 in the following applications:

Publications
Read Publications using
NBP2-49387 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Granzyme K Antibody

  • EC 3.4.21
  • EC 3.4.21.-
  • EC 3.4.21.4
  • Fragmentin-3
  • Granzyme 3
  • granzyme K (granzyme 3; tryptase II)
  • granzyme K (serine protease, granzyme 3; tryptase II)
  • Granzyme K
  • Granzyme-3
  • Granzyme-K
  • GZMK
  • NK-Tryp-2
  • NK-Tryptase-2
  • PRSS
  • TRYP2
  • TRYP2granzyme-3
  • Tryptase II

Background

The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H localizes to cytoplasmic granules of cytolytic T lymphocytes and is important for target cell lysis in cell-mediated immune responses. Granzyme K (GMZK), also designated granzyme-3 or NK-tryptase-2 (NK-TRYP-2), contains one peptidase S1 domain. Granzyme K is a serine protease localizing to the granules of natural killer cells and cytotoxic T lymphocytes. It is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Granzyme K Antibody (NBP2-49387)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Immunohistochemistry-Paraffin.


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Immunohistochemistry-Paraffin
(2)
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Human
(2)
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Review for Granzyme K Antibody (NBP2-49387) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using NBP2-49387:
Filter by Applications
IHC
(1)
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Filter by Species
Human
(1)
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Images Ratings Applications Species Date Details
Immunohistochemistry Granzyme K NBP2-49387
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5
reviewed by:
Verified Customer
IHC Human 06/16/2017
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Summary

ApplicationImmunohistochemistry
Sample Testedhuman skin
SpeciesHuman
LotR88017

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FAQs for Granzyme K Antibody (NBP2-49387) (0)

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Secondary Antibodies

 

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Recent Reviews

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1
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Verified Customer
06/16/2017
Application: IHC
Species: Human

Bioinformatics

Gene Symbol GZMK