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GnRHR Antibody (GNRHR/768) [Alexa Fluor® 350]

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GnRHR Antibody (GNRHR/768) [Alexa Fluor® 350] [NBP3-11436AF350] - Vial of Alexa Fluor 350 conjugated antibody. Alexa Fluor 350 is optimally excited at 346 nm by the UV laser (350 or 355 nm) and has an emission maximum of 442 nm.
GnRHR Antibody (GNRHR/768) [Alexa Fluor® 350] [NBP3-11436AF350] - Vial of Alexa Fluor 350 conjugated antibody. Alexa Fluor 350 is optimally excited at 346 nm by the UV laser (350 or 355 nm) and has an emission ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IHC, ICC/IF
Clone
GNRHR/768
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 350

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 405
NBP3-11436AF405
Alexa Fluor 488
NBP3-11436AF488
Alexa Fluor 532
NBP3-11436AF532
Alexa Fluor 594
NBP3-11436AF594
Alexa Fluor 647
NBP3-11436AF647
Alexa Fluor 700
NBP3-11436AF700
Alexa Fluor 750
NBP3-11436AF750
Allophycocyanin
NBP3-11436APC
Biotin
NBP3-11436B
CoraFluor 1
NBP3-11436CL1
DyLight 350
NBP3-11436UV
DyLight 405
NBP3-11436V
DyLight 488
NBP3-11436G
DyLight 550
NBP3-11436R
DyLight 594
NBP3-11436DL594
DyLight 650
NBP3-11436C
DyLight 680
NBP3-11436FR
DyLight 755
NBP3-11436IR
FITC
NBP3-11436F
HRP
NBP3-11436H
Janelia Fluor 525
NBP3-11436JF525
Janelia Fluor 549
NBP3-11436JF549
Janelia Fluor 585
NBP3-11436JF585
Janelia Fluor 635
NBP3-11436JF635
Janelia Fluor 646
NBP3-11436JF646
Janelia Fluor 669
NBP3-11436JF669
PE
NBP3-11436PE
PerCP
NBP3-11436PCP
Unconjugated
NBP2-45300-0.1mg
mFluor Violet 450 SE
NBP3-11436MFV450
mFluor Violet 500 SE
NBP3-11436MFV500
mFluor Violet 610 SE
NBP3-11436MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-45300-0.1mg
IHC-Prediluted
NBP2-48039
Azide and BSA Free
NBP3-11436
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GnRHR Antibody (GNRHR/768) [Alexa Fluor® 350] Summary

Immunogen
Recombinant full-length human GNRHR protein
Localization
Cytoplasmic
Specificity
Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GNRHR
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for GnRHR Antibody (GNRHR/768) [Alexa Fluor® 350]

  • GnRH receptor
  • GnRHR
  • GnRH-R
  • GNRHR1
  • gonadotropin-releasing hormone (type 1) receptor 1
  • gonadotropin-releasing hormone receptor
  • GRHR
  • HH7
  • leutinizing-releasing hormone receptor
  • LHRHR
  • LHRHRleutinizing hormone releasing horomone receptor
  • LRHR
  • luliberin receptor
  • Luliberin
  • type I GnRH receptor

Background

GnRHR encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Bioinformatics

Gene Symbol GNRHR