GnRHR Products

Description

GnRHR encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Bioinformatics

Entrez	2798 Human
Uniprot	NM_000406 Human P30968 Human
Product By Gene ID	2798
Alternate Names	GnRH receptor gnRH-R GnRH-R GNRHR1 gonadotropin-releasing hormone (type 1) receptor 1 gonadotropin-releasing hormone receptor GRHR leutinizing-releasing hormone receptor LHRHRleutinizing hormone releasing horomone receptor LRHR luliberin receptor type I GnRH receptor

Research Areas for GnRHR

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GPCR