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GnRHR Antibody (GNRHR/2982R) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Clone
GNRHR/2982R
Clonality
Monoclonal
Host
Rabbit
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-08770AF350
Alexa Fluor 405
NBP3-08770AF405
Alexa Fluor 488
NBP3-08770AF488
Alexa Fluor 532
NBP3-08770AF532
Alexa Fluor 594
NBP3-08770AF594
Alexa Fluor 647
NBP3-08770AF647
Alexa Fluor 700
NBP3-08770AF700
Alexa Fluor 750
NBP3-08770AF750
Allophycocyanin
NBP3-08770APC
Biotin
NBP3-08770B
DyLight 350
NBP3-08770UV
DyLight 405
NBP3-08770V
DyLight 488
NBP3-08770G
DyLight 550
NBP3-08770R
DyLight 594
NBP3-08770DL594
DyLight 650
NBP3-08770C
DyLight 680
NBP3-08770FR
DyLight 755
NBP3-08770IR
FITC
NBP3-08770F
HRP
NBP3-08770H
Janelia Fluor 525
NBP3-08770JF525
Janelia Fluor 549
NBP3-08770JF549
Janelia Fluor 585
NBP3-08770JF585
Janelia Fluor 635
NBP3-08770JF635
Janelia Fluor 646
NBP3-08770JF646
Janelia Fluor 669
NBP3-08770JF669
PE
NBP3-08770PE
PerCP
NBP3-08770PCP
Unconjugated
NBP3-07747-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-07747-100ug
Azide and BSA Free
NBP3-08770
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GnRHR Antibody (GNRHR/2982R) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant full-length human GnRHR protein
Localization
Cytoplasmic
Specificity
Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
GNRHR
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for GnRHR Antibody (GNRHR/2982R) [CoraFluor™ 1]

  • GnRH receptor
  • GnRHR
  • GnRH-R
  • GNRHR1
  • gonadotropin-releasing hormone (type 1) receptor 1
  • gonadotropin-releasing hormone receptor
  • GRHR
  • HH7
  • leutinizing-releasing hormone receptor
  • LHRHR
  • LHRHRleutinizing hormone releasing horomone receptor
  • LRHR
  • luliberin receptor
  • Luliberin
  • type I GnRH receptor

Background

GnRHR encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GNRHR