Home » Glucosylceramidase/GBA » Glucosylceramidase/GBA Antibodies » Glucosylceramidase/GBA Antibody (OTI4G4) [Janelia Fluor® 525]
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Glucosylceramidase/GBA Antibody (OTI4G4) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clone
OTI4G4
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 525

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-70803AF350
Alexa Fluor 405
NBP2-70803AF405
Alexa Fluor 488
NBP2-70803AF488
Alexa Fluor 532
NBP2-70803AF532
Alexa Fluor 594
NBP2-70803AF594
Alexa Fluor 647
NBP2-70803AF647
Alexa Fluor 700
NBP2-70803AF700
Alexa Fluor 750
NBP2-70803AF750
Biotin
NBP2-70803B
CoraFluor 1
NBP2-70803CL1
DyLight 350
NBP2-70803UV
DyLight 405
NBP2-70803V
DyLight 488
NBP2-70803G
DyLight 550
NBP2-70803R
DyLight 594
NBP2-70803DL594
DyLight 650
NBP2-70803C
DyLight 680
NBP2-70803FR
DyLight 755
NBP2-70803IR
FITC
NBP2-70803F
HRP
NBP2-70803H
Janelia Fluor 549
NBP2-70803JF549
Janelia Fluor 646
NBP2-70803JF646
Janelia Fluor 669
NBP2-70803JF669
Unconjugated
NBP2-45829
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-45829
Azide and BSA Free
NBP2-70803
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Glucosylceramidase/GBA Antibody (OTI4G4) [Janelia Fluor® 525] Summary

Immunogen
Human recombinant protein fragment corresponding to amino acids 40-315 of human GBA (NP_000148) produced in E.coli.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
GBA1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Glucosylceramidase/GBA Antibody (OTI4G4) [Janelia Fluor® 525]

  • Acid beta-glucosidase
  • Alglucerase
  • beta-glucocerebrosidase
  • D-glucosyl-N-acylsphingosine glucohydrolase
  • EC 3.2.1.45
  • GBA
  • GBA1
  • GC
  • GCB
  • GLUC
  • glucosidase, beta, acid
  • glucosidase, beta; acid (includes glucosylceramidase)
  • Glucosylceramidase
  • Imiglucerase
  • lysosomal glucocerebrosidase

Background

GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GBA1