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GLP1 Antibody (03) [Janelia Fluor® 669]

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Product Details

Summary
Reactivity MaSpecies Glossary
Applications WB, ELISA
Clone
03
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 669

Order Details

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GLP1 Antibody (03) [Janelia Fluor® 669] Summary

Immunogen
Synthetic GLP-1(9-37)
Epitope
C-terminus of GLP-1(1-37), GLP-1(7-37) and GLP-1(9-37)
Specificity
binds GLP-1(1-37), GLP-1(7-37) and GLP-1(9-37). Cross-reaction with C-terminally amidated GLP-1 is 0-16% in various circumstances.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GCG
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for GLP1 Antibody (03) [Janelia Fluor® 669]

  • glicentin-related polypeptide
  • GLP1
  • GLP-1
  • glucagon-like peptide 1
  • GRPP

Background

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GCG