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FXYD5/Dysadherin Antibody (CL14037)

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Staining of human pancreas shows strong membranous positivity in exocrine glandular cells.
Staining of human pancreas shows strong membranous positivity in exocrine glandular cells.
Staining of human breast cancer shows strong membranous positivity in tumor cells.
Staining of human ovarian cancer (papillary carcinoma) shows strong membranous positivity in tumor cells.
Staining of human tonsil shows moderate membranous positivity in lymphoid cells.
Staining of human fallopian tube shows moderate membranous and cytoplasmic positivity in glandular cells.
Staining of human ovarian cancer (high grade serous carcinoma) shows strong membranous positivity in tumor cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
CL14037
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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FXYD5/Dysadherin Antibody (CL14037) Summary

Immunogen
This antibody was designed to target the recombinant protein FXYD5/Dysadherin, with the precise immunogen sequence being withheld for proprietary reasons.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FXYD5
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For IHC-Paraffin, we recommend using Heat-Induced Epitope Retrieval (HIER) with a pH level of 6. This optimized retrieval method ensures the best results for your experiments.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for FXYD5/Dysadherin Antibody (CL14037)

  • DYSAD
  • Dysadherin
  • EF-8
  • FXYD domain containing ion transport regulator 5
  • FXYD domain-containing ion transport regulator 5
  • FXYD5
  • IWU1
  • KCT1
  • keratinocytes associated transmembrane protein 1
  • OIT2
  • PRO6241
  • RIC

Background

Dysadherin encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FXYD5/Dysadherin
Antibody (CL14037)
NBP3-24585
FXYD5/Dysadherin Antibody (CL14037)
Species: Hu
Applications: IHC

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FXYD5