FXYD5/Dysadherin Products

Description

Dysadherin encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.

Bioinformatics

Entrez	53827 Human
Uniprot	NM_014164 Human NP_001158077 Human NP_054883. Human NP_659003 Human Q96DB9 Human
Product By Gene ID	53827
Alternate Names	DYSAD dysadherin Dysadherin FXYD domain containing ion transport regulator 5 FXYD domain-containing ion transport regulator 5 IWU1 KCT1 keratinocytes associated transmembrane protein 1 OIT2 PRO6241 RIC