Fucosyltransferase 8/FUT8 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FUT8 (Fucosyltransferase 8; also alpha 1,6 Fucosyltransferase) is a 60‑65 kDa member of the glycosyltransferase 23 family of enzymes. It catalyzes the addition of fucose to Asn-linked GlcNAc via an alpha 1,6 linkage. FUT8 is widely expressed, and the effects of its fucosylation vary. A lack of fucosylation on IgG potentiates ADCC activity, while an absence of fucose on the EGF R and alpha 3 beta 1 integrin decreases their activity. Human FUT8 is a type II transmembrane protein 575 amino acids (aa) in length. It contains a short cytoplasmic region (aa 1‑9) plus an extended luminal domain (aa 31‑575) that possesses one SH3 homology domain (aa 502‑563). There are at least four potential splice variants. There is an alternate start site at Met479, a 14 aa substitution for aa 1‑420, a 32 aa substitution for aa 1‑161, and a two aa substitution for aa 444‑575. Over aa 32‑575, human FUT8 shares 97% aa identity with mouse FUT8.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, IHC.

Showing Publications 1 - 3 of 3.

Publications using AF5768	Applications	Species
J Van Coilli, T Pongracz, J Rahmöller, HJ Chen, CE Geyer, LA van Vught, JS Buhre, T Šušti?, TLJ van Osch, M Steenhuis, W Hoepel, W Wang, AS Lixenfeld, J Nouta, S Keijzer, F Linty, R Visser, MD Larsen, EL Martin, I Künsting, S Lehrian, V von Kopylo, C Kern, HB Lunding, M de Winther, N van Mourik, T Rispens, T Graf, MA Slim, RP Minnaar, MK Bomers, JJ Sikkens, APJ Vlaar, CE van der Sc, J den Dunnen, M Wuhrer, M Ehlers, G Vidarsson, Fatebenefr, UMC COVID- The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees EBioMedicine, 2022-12-16;87(0):104408. 2022-12-16 [PMID: 36529104] (Flow Cytometry, Human)	Flow Cytometry	Human
Y Huang, HL Zhang, ZL Li, T Du, YH Chen, Y Wang, HH Ni, KM Zhang, J Mai, BX Hu, JH Huang, LH Zhou, D Yang, XD Peng, GK Feng, J Tang, XF Zhu, R Deng FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer Nature Communications, 2021-05-11;12(1):2672. 2021-05-11 [PMID: 33976130] (IHC, Human)	IHC	Human
N Höti, TS Lih, J Pan, Y Zhou, G Yang, A Deng, L Chen, M Dong, RB Yang, CF Tu, MC Haffner, Q Kay Li, H Zhang A Comprehensive Analysis of FUT8 Overexpressing Prostate Cancer Cells Reveals the Role of EGFR in Castration Resistance Cancers (Basel), 2020-02-18;12(2):. 2020-02-18 [PMID: 32085441] (IHC, Human)	IHC	Human

Array AF5768

• Fucosyltransferase 8/FUT8 Antibodies
• Fucosyltransferase 8/FUT8 Lysates
• Fucosyltransferase 8/FUT8 Proteins
• Fucosyltransferase 8/FUT8 Proteins and Enzyme