Name: FRS2 [p Tyr436] Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF5126
Price: 399 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, ICC/IF
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Phosphopeptide containing human FRS2 Y436 site
Modification	p Tyr436
Specificity	Detects human, mouse, and rat FRS2 isoforms when phosphorylated at Y436.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	FRS2
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF5126	Applications	Species
Brandi, G;Relli, V;Deserti, M;Palloni, A;Indio, V;Astolfi, A;Serravalle, S;Mattiaccio, A;Vasuri, F;Malvi, D;Deiana, C;Pantaleo, MA;Cescon, M;Rizzo, A;Katoh, M;Tavolari, S; Activated FGFR2 signalling as a biomarker for selection of intrahepatic cholangiocarcinoma patients candidate to FGFR targeted therapies Scientific reports 2024-02-07 [PMID: 38326380] (Immunohistochemistry, Human)	Immunohistochemistry	Human
SJ An, J Mohanty, F Tome, Y Suzuki, I Lax, J Schlessing Heparin is essential for optimal cell signaling by FGF21 and for regulation of betaKlotho cellular stability Proceedings of the National Academy of Sciences of the United States of America, 2023-02-06;120(7):e2219128120. 2023-02-06 [PMID: 36745784] (Western Blot, Chinese Hamster, Rat)	Western Blot	Chinese Hamster, Rat
JS Park, J Choi, L Cao, J Mohanty, Y Suzuki, A Park, D Baker, J Schlessing, S Lee Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein Cell Reports, 2022-10-25;41(4):111545. 2022-10-25 [PMID: 36288716] (Western Blot, Human)	Western Blot	Human
Yanshuang Zhang, Tingyu Wu, Fan Li, Yirui Cheng, Qing Han, Xin Lu et al. FGF19 Is Coamplified With CCND1 to Promote Proliferation in Lung Squamous Cell Carcinoma and Their Combined Inhibition Shows Improved Efficacy Frontiers in Oncology 2022-04-07 [PMID: 35463335]
Hong Xiang, Abigael G. Chan, Ago Ahene, David I. Bellovin, Rong Deng, Amy W. Hsu et al. Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer mAbs 2021-11-01 [PMID: 34719330]
PCC Liu, H Koblish, L Wu, K Bowman, S Diamond, D DiMatteo, Y Zhang, M Hansbury, M Rupar, X Wen, P Collier, P Feldman, R Klabe, KA Burke, M Soloviev, C Gardiner, X He, A Volgina, M Covington, B Ruggeri, R Wynn, TC Burn, P Scherle, S Yeleswaram, W Yao, R Huber, G Hollis INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models PLoS ONE, 2020-04-21;15(4):e0231877. 2020-04-21 [PMID: 32315352] (Western Blot, Mouse)	Western Blot	Mouse
L Xu, X Meng, N Xu, W Fu, H Tan, L Zhang, Q Zhou, J Qian, S Tu, X Li, Y Lao, H Xu Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth Cell Death Dis, 2018-02-15;9(3):262. 2018-02-15 [PMID: 29449529] (Western Blot, Human)	Western Blot	Human
Ayano Kabashima, Petra Hirsova, Steven F. Bronk, Matthew C. Hernandez, Mark J. Truty, Sumera Rizvi et al. Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma Journal of Hepatology 2018-06-01 [PMID: 29408314]
Alberto Roselló-Díez, Daniel Stephen, Alexandra L Joyner Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth eLife 7/25/2017 [PMID: 28741471]
Mallika Pathania, Yan Wang, Vladimir N. Simirskii, Melinda K. Duncan beta 1‐integrin controls cell fate specification in early lens development Differentiation 2016-10-01 [PMID: 27596755]
Daesuk Chung, Fei Gao, Anil G. Jegga, Sanjoy K. Das Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a Molecular and Cellular Endocrinology 2015-01-15 [PMID: 25451979]
Jones A, Teschendorff A, Li Q, Hayward J, Kannan A, Mould T, West J, Zikan M, Cibula D, Fiegl H, Lee S, Wik E, Hadwin R, Arora R, Lemech C, Turunen H, Pakarinen P, Jacobs I, Salvesen H, Bagchi M, Bagchi I, Widschwendter M Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Med, 2013-11-12;10(11):e1001551. 2013-11-12 [PMID: 24265601] (IHC-P, Mouse)	IHC-P	Mouse
Bohrer , Laura R, Chuntova , Pavlina, Bade , Lindsey, Beadnell , Thomas C, Leon , Ronald P, Brady , Nicholas, Ryu , Yungil, Goldberg , Jodi E, Schmechel , Stephen, Koopmeiners , Joseph S, McCarthy , James B, Schwertfeger , Kathryn Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. Cancer Res, 2013-11-06;74(1):374-86. 2013-11-06 [PMID: 24197137] (IHC, Neutralization, Mouse)	IHC, Neutralization	Mouse
Nallasamy S, Li Q, Bagchi MK, Bagchi IC Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. PLoS Genet., 2012-02-23;8(2):e1002500. 2012-02-23 [PMID: 22383889] (IHC-P, Mouse)	IHC-P	Mouse
Garcia CM, Huang J, Madakashira BP, Liu Y, Rajagopal R, Dattilo L, Robinson ML, Beebe DC The function of FGF signaling in the lens placode. Dev. Biol., 2011-01-09;351(1):176-85. 2011-01-09 [PMID: 21223962] (IHC-P, Mouse)	IHC-P	Mouse
Peter Newitt, Jessica Boros, Bhavani P. Madakashira, Michael L. Robinson, Lixing W. Reneker, John W. McAvoy et al. Sef is a negative regulator of fiber cell differentiation in the ocular lens Differentiation 2010-07-01 [PMID: 20542628]
Show All 16 Publications. Collapse Publications.

FRS2 [p Tyr436] Antibody [Unconjugated]

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Carrier Free AF5126-SP