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FoxP2 Antibody (CL5310)

Images

 
Immunocytochemistry/ Immunofluorescence: FoxP2 Antibody (CL5310) [NBP2-61412] - Staining of RH-30 cells using the Anti-FOXP2 monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule and ...read more
Immunohistochemistry-Paraffin: FoxP2 Antibody (CL5310) [NBP2-61412] - Staining of mouse cerebral cortex shows strong nuclear immunoreactivity in neurons in layer 6.
Immunohistochemistry-Paraffin: FoxP2 Antibody (CL5310) [NBP2-61412] - Staining of human cerebral cortex shows nuclear immunoreactivity in neurons in layer 6.
Immunohistochemistry-Paraffin: FoxP2 Antibody (CL5310) [NBP2-61412] - Staining of human cerebral cortex shows strong nuclear immunoreactivity in neurons in layer 6.
Immunohistochemistry-Paraffin: FoxP2 Antibody (CL5310) [NBP2-61412] - Staining of human lymph node shows absence of positivity in lymphoid cells as expected (negative control).
Immunohistochemistry-Paraffin: FoxP2 Antibody (CL5310) [NBP2-61412] - Staining of mouse brain shows nuclear immunoreactivity in cortical layer 6 neurons, as well as in caudate putamen.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC
Clone
CL5310
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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FoxP2 Antibody (CL5310) Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: AQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHS
Epitope
PQAGLSPAEIQQLWK
Predicted Species
Rat (97%). Backed by our 100% Guarantee.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FOXP2
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 2-10 ug/ml
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: PFA/Triton X-100
Control Peptide
FoxP2 Recombinant Protein Antigen (NBP2-61412PEP)

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for FoxP2 Antibody (CL5310)

  • CAG repeat protein 44
  • CAGH44
  • CAGH44TNRC10forkhead box protein P2
  • DKFZp686H1726
  • forkhead box P2
  • forkhead/winged-helix transcription factor
  • FoxP2
  • SPCH1
  • TNRC10
  • trinucleotide repeat containing 10
  • Trinucleotide repeat-containing gene 10 protein

Background

FOXP2 encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol FOXP2