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FKBP12.6 Antibody [Biotin]

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Western blot shows lysates of human brain (hippocampus) tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat FKBP12.6 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF4174) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for FKBP12.6 at approximately 12.6 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.
Western blot shows lysates of human brain (hippocampus) tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat FKBP12.6 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF4174) ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Unconjugated
AF4174
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF4174
Carrier Free
AF4174
Carrier Free
AF4174-SP
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FKBP12.6 Antibody [Biotin] Summary

Immunogen
E. coli-derived recombinant human FKBP12.6
Met1-Glu108
Accession # P68106
Specificity
Detects human, mouse, and rat FKBP12.6 in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
FKBP1B
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Readout System

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP12.6 Antibody [Biotin]

  • 12.6 kDa FK506-binding protein
  • calstabin 2,12.6 kDa FKBP
  • EC 5.2.1.8
  • FK506 binding protein 1B, 12.6 kDa
  • FK506-binding protein 12.6
  • FK506-binding protein 1B (12.6 kD)
  • FK506-binding protein 1B
  • FKBP12.6
  • FKBP-12.6
  • FKBP12.6h-FKBP-12
  • FKBP1B
  • FKBP-1B
  • FKBP1L
  • FKBP9
  • Immunophilin FKBP12.6
  • OTK4
  • OTK4PPIase FKBP1B
  • peptidyl-prolyl cis-trans isomerase FKBP1B
  • PKBP1L
  • PPIase
  • rotamase

Background

FK506 binding protein, 12.6 kDa molecular weight (FKBP12.6), also called FKBP1B, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans‑ proline residues critical for proper folding of proteins. The immunosuppressant FK506 is a potent inhibitor of FKBP12.6. FKBP12.6 is localized in the sarcoplasmic reticulum associated with the Ryanodyne receptor RYR2. PKA-induced phosphorylation of RYR2 causes FKBP12.6 dissociation. In heart failure, RYR2 is hyperphosphorylated and has low levels of FKBP12.6 bound to it. Male FKBP12.6 knockout mice have cardiac hypertrophy and lethal exercise arrhythmias.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FKBP12.6 Antibody
[Biotin]
BAF4174
FKBP12.6 Antibody [Biotin]
Species: Hu, Mu, Rt
Applications: WB

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Bioinformatics

Gene Symbol FKBP1B
Uniprot