E6AP/UBE3A Products

Description

UBE3A encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Bioinformatics

Entrez	22215 Mouse 7337 Human
Uniprot	AAH09271 Human NM_000462 Human NP_000453.2 Human Q05086 Human
Product By Gene ID	7337
Alternate Names	ANCREPVE6AP AS CTCL tumor antigen se37-2 E6AP ubiquitin-protein ligase E6AP E6-AP EC 6.3.2.- FLJ26981 HPVE6A human papilloma virus E6-associated protein Human papillomavirus E6-associated protein Oncogenic protein-associated protein E6-AP Renal carcinoma antigen NY-REN-54 ubiquitin protein ligase E3A ubiquitin-protein ligase E3A

Research Areas for E6AP/UBE3A

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Transcription Factors and Regulators