E6AP/UBE3A Antibody (1077332) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ubiquitin-protein ligase E3A, also known as E6AP, is an E3 ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several key substrates for UBE3A have been identified, including BMAL1, the PML tumor suppressor, PGR, and p53/TP53 suggesting a role for UBE3A in regulation of the circadian clock, tumor regulation, transcriptional coactivation of the progesterone receptors, and regulation of neoplastic progression of cells infected by high-risk human papilloma virus (1-4). Defects in activity are linked to Angelman syndrome, a neurodevelopmental disorder, as well as autism spectrum disorders implicating a role for UBE3A in regulation of neurobiological functions (3, 5, 6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB11498

• E6AP/UBE3A Antibodies
• E6AP/UBE3A ELISA Kits
• E6AP/UBE3A Lysate
• E6AP/UBE3A Proteins
• E6AP/UBE3A Proteins and Enzyme