DNMT3A Antibody (681615)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

DNMT3A (DNA [cytosine-5]-methyltransferase 3A) is a 130 kDa member of the C5-methlytransferase family of molecules.  It is expressed both during development and in virtually all adult tissues except for small intestine.  DNMT3A is a nuclear protein that is found associated with heterochromatin.  It possesses DNA methyltransferase activity, and acts in a complex with DNMT3L in embryonic stem cells, forming a (3A)2:(3L)2 heterotetramer.  It also interacts with SETDB1 to form a transcriptional repressor.  Human DNMT3A is 912 amino acids (aa) in length.  It contains one ProTrpTrpPro domain (aa 292-350) and one ADD-type zinc finger region (aa 494-586).  There is one 100 kDa splice variant termed DNMT3a2 that contains an alternative start site at Met224, and preferentially interacts with euchromatin.  Other potential splice variants show a 16 aa substitution for aa 151-912, and a 24 aa substitution for aa 1-213.  Over aa 353-486, human DNMT3A shares 96% aa identity with mouse DNMT3A.  

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using MAB63151	Applications	Species
Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M.B. Dunuwille et al. TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors Cancer Research 2021-10-01 [PMID: 34215619]
Jiajun Zhu, Mirela Berisa, Simon Schwörer, Weige Qin, Justin R. Cross, Craig B. Thompson Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation Cell Metabolism 2019-11-01 [PMID: 31607565]

Array MAB63151

• DNMT3A Antibodies
• DNMT3A ELISA Kits
• DNMT3A Kit
• DNMT3A Lysate
• DNMT3A Proteins