Orthogonal Strategies: Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Analysis in human skin and liver tissues using NBP2-31886 antibody. Corresponding Desmocollin-3 RNA-seq data are ...read more
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human liver shows no membranous postivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human esophagus shows high expression.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human skin shows strong membranous positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human tonsil shows moderate membranous positivity in squamous epithelial cells and non-germinal center cells.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human placenta shows moderate membranous postivity in trophoblastic cells.
Human reactivity reported in scientific literature (PMID: 26380766).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Desmocollin-3 Antibody
Cadherin family member 3
CDHF3
CDHF3HT-CP
desmocollin 3
Desmocollin3
Desmocollin-3
desmocollin-4
DSC
DSC1
DSC2
DSC3
DSC4
DSC4desmocollin-3
HT-CP
Background
Desmocollin 3 is encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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