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Desmocollin-3 Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Analysis in human skin and liver tissues using NBP2-31886 antibody. Corresponding Desmocollin-3 RNA-seq data are ...read more
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human liver shows no membranous postivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human esophagus shows high expression.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human skin shows strong membranous positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human tonsil shows moderate membranous positivity in squamous epithelial cells and non-germinal center cells.
Immunohistochemistry-Paraffin: Desmocollin-3 Antibody [NBP2-31886] - Staining of human placenta shows moderate membranous postivity in trophoblastic cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

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Desmocollin-3 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: VTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINT
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DSC3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Desmocollin-3 Protein (NBP2-31886PEP)
Publications
Read Publication using
NBP2-31886 in the following applications:

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 26380766).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Desmocollin-3 Antibody

  • Cadherin family member 3
  • CDHF3
  • CDHF3HT-CP
  • desmocollin 3
  • Desmocollin3
  • Desmocollin-3
  • desmocollin-4
  • DSC
  • DSC1
  • DSC2
  • DSC3
  • DSC4
  • DSC4desmocollin-3
  • HT-CP

Background

Desmocollin 3 is encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Desmocollin-3 Antibody (NBP2-31886)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.


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IF/IHC
(1)
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Human
(1)
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Bioinformatics

Gene Symbol DSC3
Uniprot