DEPTOR/DEPDC6 Antibody

DEP domain-containing mTOR-interacting protein (DEPOR/DEPTOR/DEPDC6) is a negative regulator of the mTORC1 and mTORC2 signaling pathways that regulate cell growth, proliferation and survival. It has two DEP domains and a PDZ (DHR) domain. Loss of DEPTOR activates S6k1, Akt, and SGk1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR overexpression suppresses S6k1 but, by relieving feedback inhibition from mTORC1 to PI3k signaling, activates Akt. Consistent with many human cancers having activated mTORC1 and mTORC2 pathways, DEPTOR expression is low in most cancers. Surprisingly, DEPTOR is highly overexpressed in a subset of multiple myelomas harboring cyclin D1/D3 or c-MAF/MAFB translocations. In these cells, high DEPTOR expression is necessary to maintain PI3k and Akt activation and a reduction in DEPTOR levels leads to apoptosis. It has also been reported that DEPOR has some functional significance in Lipid Biosynthesis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-27083

• DEPTOR/DEPDC6 Antibodies
• DEPTOR/DEPDC6 Lysate
• DEPTOR/DEPDC6 Proteins