Cytokeratin 1 Antibody (LHK1) - BSA Free

Cytokeratin 1 is a heterotetramer of two type I as well as two type II keratins localized in the cell membrane and is generally associated with keratin-10 (KRT10). It has been suggested to regulate the activity of kinases such as PKC/SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). Cytokeratin 1 and its heterodimer partner KRT10 are the major constituents of 4 intermediate filament cytoskeleton in suprabasal epidermis/keratinocytes, and their upregulation precedes expression of filaggrin and cornified envelope proteins. Covalent crosslinking of cytokeratin 1 but not of KRT10 to these proteins, in addition to a complex series of lipids, ultimately forms the cornified/lipid envelope, that constitutes the epidermal barrier together with Langerhans cells. Defects in cytokeratin 1 have been linked to epidermolytic hyperkeratosis (EHK), ichthyosis hystrix Curth-Macklin type (IHCM), palmoplantar keratoderma non-epidermolytic (NEPPK), ichthyosis annular epidermolytic (AEI), palmoplantar keratoderma striate type 3 (SPPK3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-P.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NB100-2756	Applications	Species
Stefano Piazza, Giulia Martinelli, Nicole Maranta, Carola Pozzoli, Marco Fumagalli, Vincenzo Nicolaci, Elisa Sonzogni, Luca Colombo, Enrico Sangiovanni, Mario Dell’Agli, Young Bok Lee Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes International Journal of Molecular Sciences 2024-04-27 [PMID: 38731983]
Iljas J, J. R, J.A. M et al. A human skin equivalent burn model to study the effect of a nanocrystalline silver dressing on wound healing Burns 2020-07-01 [PMID: 32830005] (IHC-P, Human)	IHC-P	Human
Li X, Tang M, Zhu Q et al. The exosomal integrin alpha5beta1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration Cell Oncol (Dordr) 2020-02-21 [PMID: 32080801] (IF/IHC, Human)	IF/IHC	Human
Arita S, Hatta M, Uchida K et al. Peptidylarginine deiminase is involved in maintaining the cornified oral mucosa of rats. J. Periodont. Res. 2018-04-23 [PMID: 29687476] (Rat)		Rat
Kim HJ, Lee E, Lee M et al. Phosphodiesterase 4B plays a role in benzophenone-3-induced phototoxicity in normal human keratinocytes Toxicol. Appl. Pharmacol. 2017-11-25 [PMID: 29183759] (IF/IHC, Human)	IF/IHC	Human
Ha D, Bing SJ, Ahn G et al. Blocking Glutamate Carboxypeptidase II Inhibits Glutamate Excitotoxicity and Regulates Immune Responses in Experimental Autoimmune Encephalomyelitis FEBS J. 2016-07-22 [PMID: 27444540] (IF/IHC, Human)	IF/IHC	Human
McGovern JA, Meinert C, de Veer SJ et al. Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. Br J Dermatol 2016-07-21 [PMID: 27442805]
Hartmann-Fritsch F, Biedermann T, Braziulis E et al. A new model for preclinical testing of dermal substitutes for human skin reconstruction. Pediatr Surg Int 2013-02-01 [PMID: 23371301] (IHC-P, ICC/IF, Human, Rat)	IHC-P, ICC/IF	Human, Rat
Gannon OM, Merida de Long L, Endo-Munoz L et al. Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation. Clin Cancer Res 2013-01-15 [PMID: 23186778] (IHC-P, ICC/IF, Human)	IHC-P, ICC/IF	Human
Hartmann-Fritsch F, Hosper N, Luginbuhl J et al. Human amniotic fluid derived cells can competently substitute dermal fibroblasts in a tissue-engineered dermo-epidermal skin analog Pediatr Surg Int 2012-11-09 [PMID: 23138462] (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Braziulis E, Diezi M, Biedermann T et al. Modified Plastic Compression of Collagen Hydrogels Provides an Ideal Matrix for Clinically Applicable Skin Substitutes. Tissue Eng Part C Methods. 2012-02-02 [PMID: 22195768] (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Muller FB, Huber M, Kinaciyan T, Hausser I, Schaffrath C, Krieg T, Hohl D, Korge BP, Arin MJ. A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis. Hum Mol Genet;15(7):1133-41. 2006-04-01 [PMID: 16505000] (ICC/IF)	ICC/IF
Boelsma E, Gibbs S, Faller C, Ponec M. Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation. Acta Derm Venereol;80(2):82-8. 2000-03-01 [PMID: 10877124]
Machesney M, Tidman N, Waseem A et al. Activated keratinocytes in the epidermis of hypertrophic scars. Am J Pathol. [PMID: 9588880]
Handajani J, Tabtila U, Yunita Se Effect of Contraception on the Expression of CytokeRatin 1 in Epithelial Cells of the Palatal Mucosa and Salivary Estrogen jidmr.com 2021-01-01
Piazza S, Martinelli G, Magnavacca A et al. Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema International journal of molecular sciences 2022-08-17 [PMID: 36012541] (ICC/IF, Human) Details: Dilution used 2 ug/ml	ICC/IF	Human
Show All 16 Publications. Collapse Publications.

Array NB100-2756

• Cytokeratin 1 Antibodies
• Cytokeratin 1 ELISA Kits
• Cytokeratin 1 Proteins