Western Blot: CSE1L/CAS/Exportin-2 Antibody (2B7) [H00001434-M01] - CSE1L monoclonal antibody (M01), clone 2B7 Analysis of CSE1L expression in Hela S3 NE.
Immunocytochemistry/ Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody (2B7) [H00001434-M01] - Analysis of monoclonal antibody to CSE1L on HeLa cell. Antibody concentration 25 ug/ml.
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
CSE1L (NP_001307, 872 a.a. ~ 971 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAARVTLL
Rat reactivity reported in scientific literature (PMID: 21866187).
Packaging, Storage & Formulations
Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for CSE1L/CAS/Exportin-2 Antibody (2B7)
CAS
CASMGC117283
Cellular apoptosis susceptibility protein
chromosome segregation 1 (yeast homolog)-like
Chromosome segregation 1-like protein
CSE1 chromosome segregation 1-like (yeast)
CSE1
CSE1L
exp2
exportin-2
Importin-alpha re-exporter
MGC130037
XPO2
XPO2MGC130036
Background
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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