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Complement Component C5aR1 Antibody (S5/1) [DyLight 350]

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Product Details

Summary
Reactivity Hu, Bv, Ma, RbSpecies Glossary
Applications WB, ELISA, Flow, IP, B/N
Clone
S5/1
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 350

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Complement Component C5aR1 Antibody (S5/1) [DyLight 350] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was raised by immunizing mice with a synthetic peptide corresponding to C5a-R; amino acids: 1-31 (N terminal).
Specificity
S5/1 antibody recognizes the Complement Component C5aR1 (CD88) protein, a 43 kDa receptor of C5a component of the complement cascade.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
C5AR1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Block/Neutralize
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Complement Component C5aR1 Antibody (S5/1) [DyLight 350]

  • C5a anaphylatoxin chemotactic receptor
  • C5A
  • C5aR
  • C5a-R
  • C5AR1
  • C5ARC5a anaphylatoxin receptor
  • C5R1C5a ligand
  • CD88 antigen
  • CD88
  • complement component 5 receptor 1 (C5a ligand)
  • complement component 5 receptor 1
  • complement component 5a receptor 1
  • Complement Component C5a R1
  • Complement Component C5aR1

Background

The human anaphylatoxin C5a is a 74 residue glycopeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a can be demonstrated, rendering this molecule an important mediartor of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP binding coupled receptor that belongs to the rhodopsin supergene family. C5a receptor 1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. ESTs have been isolated from B cell/lung/testis, nerve, and placenta libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol C5AR1