Complement Component C5aR1 Products

Description

The human anaphylatoxin C5a is a 74 residue glycopeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a can be demonstrated, rendering this molecule an important mediartor of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP binding coupled receptor that belongs to the rhodopsin supergene family. C5a receptor 1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. ESTs have been isolated from B cell/lung/testis, nerve, and placenta libraries.

Bioinformatics

Entrez	113959 Rat 12273 Mouse 728 Human
Uniprot	AAH08982 Human NM_001736 Human NP_001727 Human NP_001727.1 Human P21730 Human
Product By Gene ID	728
Alternate Names	C5a anaphylatoxin chemotactic receptor C5A C5aR C5a-R C5ARC5a anaphylatoxin receptor C5R1C5a ligand CD88 antigen CD88 complement component 5 receptor 1 (C5a ligand) complement component 5 receptor 1 complement component 5a receptor 1

Research Areas for Complement Component C5aR1

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GPCR
Immunology
Innate Immunity