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Complement Component C5aR1 Antibody (P12/1) [FITC]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC
Clone
P12/1
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-66539AF350
Alexa Fluor 405
NB100-66539AF405
Alexa Fluor 488
NB100-66539AF488
Alexa Fluor 532
NB100-66539AF532
Alexa Fluor 594
NB100-66539AF594
Alexa Fluor 647
NB100-66539AF647
Alexa Fluor 700
NB100-66539AF700
Alexa Fluor 750
NB100-66539AF750
Allophycocyanin
NB100-66539APC
Biotin
NB100-66539B
CoraFluor 1
NB100-66539CL1
DyLight 350
NB100-66539UV
DyLight 405
NB100-66539V
DyLight 488
NB100-66539G
DyLight 550
NB100-66539R
DyLight 594
NB100-66539DL594
DyLight 650
NB100-66539C
DyLight 680
NB100-66539FR
DyLight 755
NB100-66539IR
HRP
NB100-66539H
Janelia Fluor 525
NB100-66539JF525
Janelia Fluor 549
NB100-66539JF549
Janelia Fluor 585
NB100-66539JF585
Janelia Fluor 635
NB100-66539JF635
Janelia Fluor 646
NB100-66539JF646
Janelia Fluor 669
NB100-66539JF669
PE
NB100-66539PE
PerCP
NB100-66539PCP
Unconjugated
NB100-66539
mFluor Violet 450 SE
NB100-66539MFV450
mFluor Violet 500 SE
NB100-66539MFV500
mFluor Violet 610 SE
NB100-66539MFV610
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Complement Component C5aR1 Antibody (P12/1) [FITC] Summary

Immunogen
C5aR - peptide: Met1 - Asn31
Localization
Multi pass membrane protein.
Specificity
Recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone P12/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31). Clone P12/1 does not inhibit the binding of C5a to its receptor.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
C5AR1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted cross-reactivities: Rhesus Monkey

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Complement Component C5aR1 Antibody (P12/1) [FITC]

  • C5a anaphylatoxin chemotactic receptor
  • C5A
  • C5aR
  • C5a-R
  • C5AR1
  • C5ARC5a anaphylatoxin receptor
  • C5R1C5a ligand
  • CD88 antigen
  • CD88
  • complement component 5 receptor 1 (C5a ligand)
  • complement component 5 receptor 1
  • complement component 5a receptor 1
  • Complement Component C5a R1
  • Complement Component C5aR1

Background

The human anaphylatoxin C5a is a 74 residue glycopeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a can be demonstrated, rendering this molecule an important mediartor of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP binding coupled receptor that belongs to the rhodopsin supergene family. C5a receptor 1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. ESTs have been isolated from B cell/lung/testis, nerve, and placenta libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol C5AR1