Human, Monkey Complement C5 ELISA Kit (Colorimetric)

This product is produced by and distributed for Abnova, a company based in Taiwan.

C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kDa glycoprotein consisting of a disulphide linked alpha-chain (115kDa) and beta-chain (75kDa). C5 occurs in plasma at about 75mg/L. It is activated via either the classical or the alternative complement pathway, by protoelytic cleavage of C5a (11.5kDa) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b,initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using KA2114	Applications	Species
Yoshikazu K, Yuta S, Sotaro M et al. Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis. Mol Ther Nucleic Acids. 2023-01-13 [PMID: 36789273]
Xu GL, Chen J, Yang F et al. C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis via potentiating Fgl2/fibroleukin expression. Hepatology. 2014-05-28 [PMID: 24604562]

Array KA2114

• Complement C5 Antibodies
• Complement C5 ELISA Kits
• Complement C5 Lysate
• Complement C5 Proteins