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Complement C5 Antibody (lendalizumab) - Humanized, IgG2SA

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
lendalizumab
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-28576AF350
Alexa Fluor 405
NBP3-28576AF405
Alexa Fluor 488
NBP3-28576AF488
Alexa Fluor 532
NBP3-28576AF532
Alexa Fluor 594
NBP3-28576AF594
Alexa Fluor 647
NBP3-28576AF647
Alexa Fluor 700
NBP3-28576AF700
Alexa Fluor 750
NBP3-28576AF750
Allophycocyanin
NBP3-28576APC
Biotin
NBP3-28576B
CoraFluor 1
NBP3-28576CL1
DyLight 350
NBP3-28576UV
DyLight 405
NBP3-28576V
DyLight 488
NBP3-28576G
DyLight 550
NBP3-28576R
DyLight 594
NBP3-28576DL594
DyLight 650
NBP3-28576C
DyLight 680
NBP3-28576FR
DyLight 755
NBP3-28576IR
FITC
NBP3-28576F
HRP
NBP3-28576H
Janelia Fluor 525
NBP3-28576JF525
Janelia Fluor 549
NBP3-28576JF549
Janelia Fluor 646
NBP3-28576JF646
Janelia Fluor 669
NBP3-28576JF669
PE
NBP3-28576PE
PerCP
NBP3-28576PCP
mFluor Violet 450 SE
NBP3-28576MFV450
mFluor Violet 500 SE
NBP3-28576MFV500
mFluor Violet 610 SE
NBP3-28576MFV610
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Complement C5 Antibody (lendalizumab) - Humanized, IgG2SA Summary

Description
Expressed from CHO. The heavy chain type is huIgG2, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'lendalizumab'.

IgG2SA is human IgG2 with S378A mutation.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
Complement C5
Isotype
IgG2
Clonality
Monoclonal
Host
Human
Gene
C5
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for Complement C5 Antibody (lendalizumab) - Humanized, IgG2SA

  • anaphylatoxin C5a analog
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
  • C5
  • complement C5
  • complement component 5
  • CPAMD4MGC142298
  • FLJ17816
  • FLJ17822

Background

C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kDa glycoprotein consisting of a disulphide linked alpha-chain (115kDa) and beta-chain (75kDa). C5 occurs in plasma at about 75mg/L. It is activated via either the classical or the alternative complement pathway, by protoelytic cleavage of C5a (11.5kDa) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b,initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ARHGAP4 Antibody
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PFDN4 Antibody -
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Complement
Component C9 Antibody
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Secondary Antibodies

 

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Bioinformatics

Gene Symbol C5
Uniprot