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Chorein Antibody

Images

 
Immunohistochemistry-Paraffin: Chorein Antibody [NBP1-85641] - Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: Chorein Antibody [NBP1-85641] - Staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Chorein Antibody [NBP1-85641] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
Immunohistochemistry-Paraffin: Chorein Antibody [NBP1-85641] - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Chorein Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: RPPRFFNEDGVIRPYRLRDGTGNQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTCEWQYSFDEFTKEPFIVHGRRLRIEAKERVKSVF
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
VPS13A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence Reported in scientific literature (PMID: 30093493)
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot Reported in scientific literature (PMID: 31192303)
Application Notes
IHC-P-Retrieval method: HIER pH6
Publications
Read Publications using
NBP1-85641 in the following applications:

  • 2 publications
  • IP
    1 publication
  • WB
    4 publications

Reactivity Notes

Mouse reactivity reported in the scientific literature (PMID: 29928881).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Chorein Antibody

  • CHAC
  • chorea-acanthocytosis protein
  • vacuolar protein sorting 13 homolog A (S. cerevisiae)
  • vacuolar protein sorting 13A

Background

Chorein may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Chorein Antibody (NBP1-85641)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, IP, WB.


Filter By Application
ICC/IF
(2)
IP
(1)
WB
(4)
All Applications
Filter By Species
Human
(6)
Mouse
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using NBP1-85641 Applications Species
Nguyen TT, Voeltz GK. An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion eLife 2022-11-30 [PMID: 36448541]
GuillEn-Samander A, Wu Y, Pineda SS et al. A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane Proceedings of the National Academy of Sciences of the United States of America 2022-08-30 [PMID: 35994651] (ICC/IF, Human) ICC/IF Human
Shahi I, Llaneras CN, Perelman SS et al. Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae beta-Hemolysin/Cytolysin-Induced Cell Death Microbiology spectrum 2022-02-23 [PMID: 35196804] (WB, Human) WB Human
Ryoden Y, Segawa K, Nagata S Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells Proceedings of the National Academy of Sciences of the United States of America 2022-02-15 [PMID: 35140185]
Tada Y, Hamaguchi T, Ikeda Y et al. Chorea-acanthocytosis with a novel mutation in the vacuolar protein sorting 13 homolog a gene: A case report J. Neurol. Sci. 2020-02-20 [PMID: 32088470] (WB, Human) WB Human
Frischknecht L, Britschgi C, Galliker P et al. Novel pathogenic VPS13A gene mutations in Japanese patients with chorea-acanthocytosis Neurol Genet 2019-06-01 [PMID: 31192303] (WB, Human) WB Human
Kumar N, Leonzino M, Hancock-Cerutti W et al. VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites J. Cell Biol. 2018-08-09 [PMID: 30093493] (ICC/IF, Human) ICC/IF Human
Nagata O, Nakamura M, Sakimoto H et al. Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece Biochem. Biophys. Res. Commun. 2018-06-21 [PMID: 29928881] (Mouse) Mouse
Sasaki N, Nakamura M, Kodama A et al. Chorein interacts with a-tubulin and histonedeacetylase 6, and overexpression preserves cellviability during nutrient deprivation in humanembryonic kidney 293 cells FASEB J. 2016-11-01 [PMID: 27468757] (WB, IP, Human) WB, IP Human

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol VPS13A