Caspase-6 Antibody

Caspases belong to the cysteine-aspartic acid protease (Caspase) family which plays a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream. Caspase-3 (CASP3/CPP32) and Caspase-6 (CASP6/Mch2) are the major active caspases in apoptotic cells and are activated in response to distinct apoptosis-inducing stimuli and in all cell, lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Mch2 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Canine.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-56114	Applications	Species
Berta T, Park CK, Xu ZZ et al. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J. Clin. Invest. 2014-03-03 [PMID: 24531553] (WB, Mouse) Details: WB (mouse spinal cord tissue, cerebral fluid and recombinant Caspase-6), Figs 2C-F, S1. The Caspase-6 pAb was used at 1:2000. The specificity of the antibody was validated with recombinant caspase-6 by WB (Fig 2E). Pro-caspase-6 was detected at ~37kDa, an	WB	Mouse
Saggar JK, Tannock IF. Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy. Int J Cancer. 2013-11-08 [PMID: 24338277] (IHC-Fr, ICC/IF, Human)	IHC-Fr, ICC/IF	Human
Saggar JK, Fung AS, Patel KJ, Tannock IFet al. Use of molecular biomarkers to quantify the spatial distribution of effects of anticancer drugs in solid tumors. Mol Cancer Ther 2013-04-01 [PMID: 23348047] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Krajewska M, Rosenthal RE, Mikolajczyk J et al. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol. 2004-10-01 [PMID: 15380478] (IHC-P, WB, Rat, Canine, Mouse) Details: Antibodies cited: 1. Caspase-9 (Active/Cleaved), IMG-5705: WB: Fig 1A (recombinant human caspase-9), Fig 4A (recombinant human caspase-9, rat brain), Fig 4B-F (isolated mitochondria from rat liver or heart). Fig 5 (PC12 cells) IHC (P): Fig 2d-k (rat kidne	IHC-P, WB	Rat, Canine, Mouse

Array NB100-56114

• Caspase-6 Antibodies
• Caspase-6 ELISA Kit
• Caspase-6 Lysate
• Caspase-6 Proteins