Canine IL-18 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

Array DY29241-05

• IL-18/IL-1F4 Antibodies
• IL-18/IL-1F4 Antibody Pairs
• IL-18/IL-1F4 ELISA Kits
• IL-18/IL-1F4 Lysate
• IL-18/IL-1F4 Protein
• IL-18/IL-1F4 ELISAs
• IL-18/IL-1F4 Proteins and Enzymes