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Cadherin-17 Antibody (10C12) - Humanized

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Immobilized human Cadherin-17,  His Tag at 2 ug/mL can bind Cadherin-17 Antibody (10C12) - Humanized, EC50=0.00468 ug/mL.
Immobilized human Cadherin-17,  His Tag at 2 ug/mL can bind Cadherin-17 Antibody (10C12) - Humanized, EC50=0.00468 ug/mL.
The endocytosis ratio 10C12 by Human CDH17 HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 80% at antibody concentration of 2 nM.
10C12 inhibited the tumor growth of COLO205 on nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 70.0% at 5 mpk at D26.
Human Cadherin-17 HEK293 cells were stained with Cadherin-17 Antibody (10C12) - Humanized and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.06889 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
10C12
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-28819AF350
Alexa Fluor 405
NBP3-28819AF405
Alexa Fluor 488
NBP3-28819AF488
Alexa Fluor 532
NBP3-28819AF532
Alexa Fluor 594
NBP3-28819AF594
Alexa Fluor 647
NBP3-28819AF647
Alexa Fluor 700
NBP3-28819AF700
Alexa Fluor 750
NBP3-28819AF750
Allophycocyanin
NBP3-28819APC
Biotin
NBP3-28819B
CoraFluor 1
NBP3-28819CL1
DyLight 350
NBP3-28819UV
DyLight 405
NBP3-28819V
DyLight 488
NBP3-28819G
DyLight 550
NBP3-28819R
DyLight 594
NBP3-28819DL594
DyLight 650
NBP3-28819C
DyLight 680
NBP3-28819FR
DyLight 755
NBP3-28819IR
FITC
NBP3-28819F
HRP
NBP3-28819H
Janelia Fluor 525
NBP3-28819JF525
Janelia Fluor 549
NBP3-28819JF549
Janelia Fluor 585
NBP3-28819JF585
Janelia Fluor 635
NBP3-28819JF635
Janelia Fluor 646
NBP3-28819JF646
Janelia Fluor 669
NBP3-28819JF669
PE
NBP3-28819PE
PerCP
NBP3-28819PCP
mFluor Violet 450 SE
NBP3-28819MFV450
mFluor Violet 500 SE
NBP3-28819MFV500
mFluor Violet 610 SE
NBP3-28819MFV610
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Cadherin-17 Antibody (10C12) - Humanized Summary

Description
Expressed from CHO. The heavy chain type is IgG1, and the light chain type is hukappa. It has a predicted MW of 143.68kDa.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
CDH17 / Cadherin-17
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Gene
CDH17
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for Cadherin-17 Antibody (10C12) - Humanized

  • cadherin 17, LI cadherin (liver-intestine)
  • cadherin
  • cadherin-16
  • Cadherin17
  • Cadherin-17
  • CDH16
  • CDH17
  • FLJ26931
  • HPT-1 cadherin
  • HPT1
  • HPT-1
  • human intestinal peptide-associated transporter HPT-1
  • human peptide transporter 1
  • Intestinal peptide-associated transporter HPT-1
  • LI cadherin
  • LI-cadherin
  • Liver-intestine cadherin
  • MGC138218
  • MGC142024

Background

LI Cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu
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Bioinformatics

Gene Symbol CDH17
Uniprot