Recombinant Human BRCA1 GST (N-Term) Protein

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publication 1 - 1 of 1.

Publication using H00000672-P01	Applications	Species
Zhu Q, Han SX, Zhou CY et al. Autoimmune response to PARP and BRCA1/BRCA2 in cancer. Oncotarget 2015-05-10 [PMID: 25865228] (IF/IHC, Human)	IF/IHC	Human

Array H00000672-P01

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