BMP-10 Antibody (462732) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone morphogenetic protein 10 (BMP-10) is a TGF-beta superfamily member whose expression is restricted to the developing and postnatal heart. It is synthesized as a 424 amino acid (aa) pre-proprotein with a putative 21 aa signal peptide, a 295 aa propeptide, and a 108 aa mature protein. Mature BMP-10 is secreted as a 25 kDa disulfide-linked homodimer. Mature human BMP-10 shares 98% aa sequence identity with mature mouse, and rat BMP-10.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 4 applications: ELISA (detection), ELISA Capture, Neutralization, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using MAB2926	Applications	Species
Dinakaran, S;Zhao, H;Tang, Y;Wang, Z;Ruiz, S;Nomura-Kitabayashi, A;Blanc, L;Faughnan, ME;Marambaud, P; CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia bioRxiv : the preprint server for biology 2023-09-16 [PMID: 37745444] (Neutralization, Transgenic Mouse, Mouse)	Neutralization	Transgenic Mouse, Mouse
J Guo, B Liu, M Thorikay, M Yu, X Li, Z Tong, RM Salmon, RJ Read, P Ten Dijke, NW Morrell, W Li Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10 Nature Communications, 2022-05-03;13(1):2395. 2022-05-03 [PMID: 35504921] (ELISA Capture, Human)	ELISA Capture	Human
Joshua Hodgson, Lidia Ruiz‐Llorente, Jamie McDonald, Oliver Quarrell, Kelechi Ugonna, James Bentham et al. Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an “HHT‐like” syndrome in children Molecular Genetics & Genomic Medicine 2021-12-01 [PMID: 33834622]
NE Owen, GJ Alexander, S Sen, K Bunclark, G Polwarth, J Pepke-Zaba, AP Davenport, NW Morrell, PD Upton Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis EBioMedicine, 2020-05-23;56(0):102794. 2020-05-23 [PMID: 32454407] (ELISA (detection), Human)	ELISA (detection)	Human
E Tillet, M Ouarné, A Desroches-, C Mallet, M Subileau, R Didier, A Lioutsko, G Belthier, JJ Feige, S Bailly A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma J. Biol. Chem., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789425] (Western Blot, Human)	Western Blot	Human
Medet Jumabay, Jiayinaguli Zhumabai, Nurlan Mansurov, Katharine C. Niklason, Pierre J. Guihard, Mark R. Cubberly et al. Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells Journal of Cellular Physiology 2018-03-01 [PMID: 28464239]
A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10 Sci Rep, 2016-11-22;5(0):37366. 2016-11-22 [PMID: 27874028] (Neutralization, Mouse)	Neutralization	Mouse
Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015-06-08;112(25):E3207-15. 2015-06-08 [PMID: 26056270] (Neutralization, Mouse)	Neutralization	Mouse
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood, 2012-05-07;119(25):6162-71. 2012-05-07 [PMID: 22566602] (Neutralization, Mouse)	Neutralization	Mouse
Kahr PC, Piccini I, Fabritz L, Greber B, Scholer H, Scheld HH, Hoffmeier A, Brown NA, Kirchhof P Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue. PLoS ONE, 2011-10-19;6(10):e26389. 2011-10-19 [PMID: 22039477] (Western Blot, Human)	Western Blot	Human

Array MAB2926

• BMP-10 Antibodies
• BMP-10 ELISA Kit
• BMP-10 Lysate
• BMP-10 Proteins and Enzymes
• BMP-10 ELISA