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beta-TrCP1/BTRC Antibody (OTI2H2) [mFluor Violet 610 SE]

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beta-TrCP1/BTRC Antibody (OTI2H2) [mFluor Violet 610 SE] [NBP2-71402MFV610] - Vial of mFluor Violet 610 conjugated antibody. mFluor Violet 610 is optimally excited at 421 nm by the Violet laser (405 nm) and has an ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, ICC/IF
Clone
OTI2H2
Clonality
Monoclonal
Host
Mouse
Conjugate
mFluor Violet 610 SE

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beta-TrCP1/BTRC Antibody (OTI2H2) [mFluor Violet 610 SE] Summary

Immunogen
Human recombinant protein fragment corresponding to amino acids 52-354 of human BTRC(NP_378663) produced in E.coli.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
BTRC
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for beta-TrCP1/BTRC Antibody (OTI2H2) [mFluor Violet 610 SE]

  • beta-transducin repeat containing
  • betaTrCP
  • BETA-TRCP
  • betaTrCP1
  • beta-TrCP1
  • BTRC
  • BTRCP
  • bTrCP1
  • E3RSIkappaB
  • F-box and WD repeats protein beta-TrCP
  • F-box/WD repeat-containing protein 1A
  • FBW1A
  • FBXW1
  • FBXW1A
  • FBXW1ABTRCP
  • FWD1
  • MGC4643
  • pIkappaBalpha-E3 receptor subunit

Background

betaTrCP encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for beta-TrCP1/BTRC Antibody (NBP2-71402MFV610) (0)

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Secondary Antibodies

 

Isotype Controls

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mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol BTRC