BAFF/BLyS/TNFSF13B Antibody (121808) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BAFF (also known as TALL-1, BLyS, THANK) is a 34-36 kDa type II transmembrane glycoprotein belonging to the BAFF family of the TNF superfamily, and has been designated as TNF superfamily member 13B (TNFSF13B). Mouse BAFF is a 309 amino acid (aa) protein consisting of a 248 aa extracellular domain, a 21 aa transmembrane region and a 45 aa cytoplasmic tail. BAFF has the typical structural characteristics of the TNF superfamily ligands. It is a homotrimeric protein having the structurally conserved motif known as TNF homology domain. Mouse BAFF may be shed from the cell surface by proteolytic cleavage between R126 and Ala 127 to yield a soluble form of the protein detectable in serum. Within the TNF superfamily, BAFF shares the highest homology (48%) with APRIL, the only other member of the BAFF family of molecules. BAFF and APRIL both bind to BCMA and TACI, while BAFF also binds specifically to BAFF receptor (BAFF R, also known as BR3 or TNFSFR13C), which represents the principal BAFF receptor. All three receptors are type III transmembrane proteins that are expressed on B cells, monocytes, osteoclasts, activated T cells, adipocytes, keratinocytes and microglia. BAFF and APRIL can form active heteromers that bind TACI. BAFF is expressed by monocytes, osteoclasts, astrocytes, neutrophils, follicular T helper cells, dendritic cells and specialized fibroblasts. Its expression in resting monocytes is upregulated by IFN-alpha , IFN-beta , LPS and IL-10. BAFF provides critical survival signals to a subset of B cells with intermediate maturation status (T2 B cells) during the immune response. BAFF also plays an important role in the development of lymphoid tissue and enhances the survival of activated memory B cells. Recent reports also show a role for BAFF in osteoclast formation. Over aa 127-309, mouse BAFF shares 93 and 72% aa sequence identity with rat and human BAFF, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 2 of 2.

Publications using IC1357P	Applications	Species
Notley CA, Baker N, Ehrenstein MR Secreted IgM enhances B cell receptor signaling and promotes splenic but impairs peritoneal B cell survival. J. Immunol., 2010-03-05;184(7):3386-93. 2010-03-05 [PMID: 20207998] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. J. Immunol., 2008-07-15;181(2):976-90. 2008-07-15 [PMID: 18606649] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array IC1357P

• BAFF/BLyS/TNFSF13B Antibodies
• BAFF/BLyS/TNFSF13B Antibody Pair
• BAFF/BLyS/TNFSF13B ELISA Kits
• BAFF/BLyS/TNFSF13B Lysate
• BAFF/BLyS/TNFSF13B Proteins
• BAFF/BLyS/TNFSF13B ELISAs
• BAFF/BLyS/TNFSF13B Proteins and Enzymes