BACE-1 Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BACE-1 (beta‑site APP cleaving enzyme-1) is an aspartic protease and an integral membrane protein (1, 2). It is the major beta  secretase, and together with the gamma secretase, is responsible for generating the amyloid beta peptide (A beta ) from the amyloid precursor protein (APP) (3, 4). Because A beta is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. High levels of BACE-1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo, indicating that inhibiting BACE-1 may block not only A beta -dependent but also A beta -independent pathogenic mechanisms (5). In addition to APP, BACE-1 also cleaves APP-like proteins 1 and 2, the cell adhesion protein P-selectin glycoprotein ligand-1 and beta -galactoside alpha 2,6-sialyltransferase, implying that BACE-1 may have additional functions involving the ectodomain shedding of membrane proteins (6‑8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Development.

Showing Publications 1 - 2 of 2.

Publications using BAF931	Applications	Species
Lei Liu, Bianca M. Lauro, Li Ding, Matteo Rovere, Michael S. Wolfe, Dennis J. Selkoe Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life Alzheimer's & Dementia 9/1/2019 [PMID: 31416794]
Ahmed RR, Holler CJ, Webb RL BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J. Neurochem., 2009-12-04;112(4):1045-53. 2009-12-04 [PMID: 19968762] (ELISA Development, Human)	ELISA Development	Human

Array BAF931

• BACE-1 Antibodies
• BACE-1 ELISA Kits
• BACE-1 Lysate
• BACE-1 Protein
• BACE-1 ELISA
• BACE-1 Proteins and Enzymes