| Reactivity | HuSpecies Glossary |
| Applications | WB, IP |
| Clone | 324802 |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugate | Unconjugated |
| Concentration | LYOPH |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Arylsulfatase A/ARSA Arg19-Ala507 Accession # AAH14210 |
| Specificity | Detects human Arylsulfatase A/ARSA in direct ELISAs and Western blots. In direct ELISAs and Western blots, 20‑50% cross‑reactivity with recombinant mouse ARSA is observed. |
| Source | N/A |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | ARSA |
| Purity Statement | Protein A or G purified from hybridoma culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Publications |
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| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | No Preservative |
| Concentration | LYOPH |
| Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms (2). The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507) (3). Human ARSA has a predicted molecular mass of approximately 53 kDa and an apparent molecular mass of approximately 63 kDa in SDS-PAGE. The amino acid sequence of human ARSA shares 92%, 89%, 87%, and 86% identity with porcine, canine, mouse, and rat ARSA.
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Secondary Antibodies |
Isotype Controls |
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