Aquaporin-2 [p Ser261] Antibody - Azide Free

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein aquaporins. Aquaporin 0, and Aquaporin 1 have been the foundation of the growing family of aquaporins. The lens specific Aquaporin 0 represents up to 80% of total lens membrane protein. Defects in Aquaporin 0 are a cause of autosomal dominant cataract. The lens opacity mutation is an AA substitution that inhibits targeting of MIP to the cell membrane. Human Aquaporin 0 is a 263 amino acid transmembrane protein belonging to the MIP family. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C terminus are predicted to be cytoplasmic. Aquaporin 2 is located in the collecting tubule.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Canine.

We have publications tested in 3 applications: Cytometric Bead Assay Standard, IF/IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-61100	Applications	Species
Ranieri M, Venneri M, Pellegrino T et al. The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation Cells 2020-05-29 [PMID: 32486031]
Centrone M, Ranieri M, Di Mise A et al. AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70 Cell. Physiol. Biochem. 2017-11-17 [PMID: 29145196] (IF/IHC)	IF/IHC
Ranieri M, Tamma G, Di Mise A et al. Negative feedback from CaSR signaling to Aquaporin-2 confers high sensitivity of vasopressin to extracellular calcium. J. Cell. Sci. 2015-05-14 [PMID: 25977473] (WB, Human)	WB	Human
Trimpert C, van den Berg DT, Fenton RA et al. Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus Nephrol Dial Transplant 2012-07-09 [PMID: 22778181] (Cytometric Bead Assay Standard, WB, Canine)	Cytometric Bead Assay Standard, WB	Canine

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Grazia Tamma	WB	Human	04/06/2016	View Summary Application Western Blot Species Human

Array NB100-61100

• Aquaporin-2 Antibodies
• Aquaporin-2 ELISA Kits
• Aquaporin-2 Proteins