Apolipoprotein A5 Antibody (1G5G9)

Apolipoprotein A-V (APOA5) belongs to apolipoprotein A1/A4/E family and is a component of several lipoprotein fractions, including VLDL, HDL and chylomicrons. Expressed at high levels in plasma and liver, APOA5 exists as a secreted protein and interacts with GPIHBP1. APOA5 is an important determinant of plasma triglyceride levels by both behaving as a potent stimulator of apo-CII lipoprotein lipase/LPL TG hydrolysis and an inhibitor of hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). APOA5 activates lecithin: cholesterol acyltransferase (LCAT) but does not enhance efflux of cholesterol from macrophages. Transgenic mice overexpressing human APOA5 gene exhibit one-third lower plasma TG levels than wild type, whereas APOA5 knockout mice possess four times as much plasma TG levels, with no effect on plasma cholesterol levels. Clinically, defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR) and hyperlipoproteinemia type 5 (HLPP5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, Immunohistochemistry-Frozen.

Showing Publications 1 - 3 of 3.

Publications using NB400-139	Applications	Species
Corbacho-Alonso N, Sastre-Oliva T, López-Almodovar LF et al. Diabetes Mellitus and Aortic Stenosis head to head: toward personalized medicine in patients with both pathologies Translational research : the journal of laboratory and clinical medicine 2023-04-19 [PMID: 37085047] (Immunohistochemistry-Frozen, Human)	Immunohistochemistry-Frozen	Human
Zheng XY, Yu BL, Xie YF et al. Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes. Mol Med Rep. 2017-11-01 [PMID: 28901468] (IF/IHC, Human)	IF/IHC	Human
Pennacchio, LA et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science;294(5540):169-73. 2001-10-05 [PMID: 11588264]

Array NB400-139

• Apolipoprotein A5 Antibodies
• Apolipoprotein A5 ELISA Kits
• Apolipoprotein A5 Lysate
• Apolipoprotein A5 Protein