Androgen R/NR3C4 Antibody (523339) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The ligand binding domain of human AR (aa 661-920) shares 100% aa sequence identity with mouse and rat AR. AR (Androgen receptor) is a 99 kDa (predicted) member of the NR3 subfamily, nuclear hormone receptor family of proteins. Due to a high number of Gln and Pro residues, it runs anomalously at 100‑120 kDa in SDS-PAGE. It is widely expressed, being found in neurons, endothelial cells, osteoblasts, chrondrocytes, mascrophages, adipocytes, and prostate epithelium. Human AR is 919 amino acids (aa) in length. It contains three discrete domains: a "modulating" N‑terminus (aa 1‑553) that is rich in Gln, Pro and Gly, a Zn-finger DNA-binding region (aa 554‑635), and a ligand-binding domain (aa 672‑917). AR is highly polymorphic at the N‑terminus, with total Gln and Gly residues differing by seven or more residues among individuals. Multiple potential splice forms exist, including an alternative start site at Met189 and a seven aa substitution for aa 1‑538 that generates a 45 kDa isoform. AR does homodimerize, apparently with multiple isotypes. Over aa 661‑920, human and mouse are identical in aa sequence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 2 of 2.

Publications using MAB5876	Applications	Species
Phong Duong, Mavis A. A. Tenkorang, Jenny Trieu, Clayton McCuiston, Nataliya Rybalchenko, Rebecca L. Cunningham Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment Biology of Sex Differences 2020-12-01 [PMID: 32223745]
Rode I, Boehm T Regenerative capacity of adult cortical thymic epithelial cells. Proc. Natl. Acad. Sci. U.S.A., 2012-02-13;109(9):3463-8. 2012-02-13 [PMID: 22331880] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array MAB5876

• Androgen R/NR3C4 Antibodies
• Androgen R/NR3C4 ELISA Kit
• Androgen R/NR3C4 Lysates
• Androgen R/NR3C4 Proteins