Name: Alkaline Phosphatase/ALPL Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF2910
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	WB, Flow, IHC, IP, CyTOF-ready, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse Alkaline Phosphatase/ALPL Phe18-Gly503 Accession # P09242
Specificity	Detects mouse Alkaline Phosphatase/ALPL in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	ALPL
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF2910	Applications	Species
Arend W. Overeem, Yolanda W. Chang, Ioannis Moustakas, Celine M. Roelse, Sanne Hillenius, Talia Van Der Helm et al. Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay Cell Reports Methods 2023-06-26 [PMID: 37426764]
Yu, Y;Rong, K;Yao, D;Zhang, Q;Cao, X;Rao, B;Xia, Y;Lu, Y;Shen, Y;Yao, Y;Xu, H;Ma, P;Cao, Y;Qin, A; The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase Nature communications 2023-07-08 [PMID: 37422472] (Western Blot, Human)	Western Blot	Human
Sun, L;Zhang, X;Wu, S;Liu, Y;Guerrero-Juarez, CF;Liu, W;Huang, J;Yao, Q;Yin, M;Li, J;Ramos, R;Liao, Y;Wu, R;Xia, T;Zhang, X;Yang, Y;Li, F;Heng, S;Zhang, W;Yang, M;Tzeng, CM;Ji, C;Plikus, MV;Gallo, RL;Zhang, LJ; Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell reports 2023-06-16 [PMID: 37330908]
Can Wang, Qin Zhao, Chen Chen, Jiaojiao Li, Jing Zhang, Shuyuan Qu et al. CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment International Journal of Oral Science 2023-05-17 [PMID: 37198150]
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton bioRxiv 2023-05-07 [PMID: 36711531]
Z Awida, S Hiram-Bab, A Bachar, H Saed, D Zyc, A Gorodov, N Ben-Califa, S Omari, J Omar, L Younis, JA Iden, L Graniewitz, I Gluzman, T Liron, B Raphael-Mi, A Kolomansky, M Rauner, B Wielockx, Y Gabet, D Neumann Erythropoietin Receptor (EPOR) Signaling in the Osteoclast Lineage Contributes to EPO-Induced Bone Loss in Mice International Journal of Molecular Sciences, 2022-10-10;23(19):. 2022-10-10 [PMID: 36233351] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
E Puissant, F Gilis, V Tevel, JM Vandeweerd, B Flamion, M Jadot, M Boonen Hyaluronidase 1 deficiency decreases bone mineral density in mice Oncogene, 2022-06-16;12(1):10142. 2022-06-16 [PMID: 35710820] (IHC, Mouse)	IHC	Mouse
S Lin, S Yin, J Shi, G Yang, X Wen, W Zhang, M Zhou, X Jiang Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration Bioactive materials, 2022-03-24;18(0):116-127. 2022-03-24 [PMID: 35387176] (IHC, Mouse)	IHC	Mouse
Y Chen, H Wang, Q Yang, W Zhao, Y Chen, Q Ni, W Li, J Shi, W Zhang, L Li, Y Xu, H Zhang, D Miao, L Xing, W Sun Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis Theranostics, 2022-01-01;12(3):1074-1096. 2022-01-01 [PMID: 35154475] (IHC, Human)	IHC	Human
Z Awida, A Bachar, H Saed, A Gorodov, N Ben-Califa, M Ibrahim, A Kolomansky, JA Iden, L Graniewitz, T Liron, S Hiram-Bab, M Brines, Y Gabet, D Neumann The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice International Journal of Molecular Sciences, 2021-12-21;23(1):. 2021-12-21 [PMID: 35008482] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
LS Chen, M Zhang, P Chen, XF Xiong, PQ Liu, HB Wang, JJ Wang, J Shen The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG Acta pharmacologica Sinica, 2021-08-30;0(0):. 2021-08-30 [PMID: 34462564] (IHC, Mouse)	IHC	Mouse
Y Sun, JF Rahbani, MP Jedrychows, CL Riley, S Vidoni, D Bogoslavsk, B Hu, PA Dumesic, X Zeng, AB Wang, NH Knudsen, CR Kim, A Marasciull, JL Millán, ET Chouchani, L Kazak, BM Spiegelman Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine Nature, 2021-05-12;0(0):. 2021-05-12 [PMID: 33981039] (Western Blot, Mouse)	Western Blot	Mouse
Ilia A. Droujinine, Amanda S. Meyer, Dan Wang, Namrata D. Udeshi, Yanhui Hu, David Rocco et al. Proteomics of protein trafficking by in vivo tissue-specific labeling Nature Communications 2021-04-22 [PMID: 33888706]
X Yang, F Zhou, P Yuan, G Dou, X Liu, S Liu, X Wang, R Jin, Y Dong, J Zhou, Y Lv, Z Deng, S Liu, X Chen, Y Han, Y Jin T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance Bioactive materials, 2021-03-10;6(10):3150-3163. 2021-03-10 [PMID: 33778195] (Western Blot, Mouse)	Western Blot	Mouse
Liangcong Hu, Jing Liu, Hang Xue, Adriana C. Panayi, Xudong Xie, Ze Lin et al. miRNA-92a-3p regulates osteoblast differentiation in patients with concomitant limb fractures and TBI via IBSP/PI3K-AKT inhibition Molecular Therapy - Nucleic Acids 2021-03-05 [PMID: 33717654]
S Yu, J Guo, Z Sun, C Lin, H Tao, Q Zhang, Y Cui, H Zuo, Y Lin, S Chen, H Liu, Z Chen BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation Cell Death & Disease, 2021-02-19;12(2):197. 2021-02-19 [PMID: 33608506] (IHC, Mouse)	IHC	Mouse
Jukka Pajarinen, Tzuhua Lin, Akira Nabeshima, Taishi Sato, Emmanuel Gibon, Eemeli Jämsen et al. Interleukin‐4 repairs wear particle induced osteolysis by modulating macrophage polarization and bone turnover Journal of Biomedical Materials Research Part A 2021-08-01 [PMID: 33340244]
S Takeyari, T Kubota, Y Ohata, M Fujiwara, T Kitaoka, Y Taga, K Mizuno, K Ozono 4-phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts J Biol Chem, 2020-11-23;0(0):. 2020-11-23 [PMID: 33154166] (Western Blot, Human)	Western Blot	Human
L Zhang, M Qi, J Chen, J Zhao, L Li, J Hu, Y Jin, W Liu Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss Stem Cell Res Ther, 2020-07-03;11(1):269. 2020-07-03 [PMID: 32620134] (Western Blot, Human)	Western Blot	Human
Xinyu Qiu, Jin Liu, Chenxi Zheng, Yuting Su, Lili Bao, Bin Zhu et al. Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis Cell Proliferation 2020-08-01 [PMID: 32608556]
G Voicu, D Rebleanu, CA Constantin, EV Fuior, L Ciortan, I Droc, CM Uritu, M Pinteala, I Manduteanu, M Simionescu, M Calin Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells Pharmaceutics, 2020-06-02;12(6):. 2020-06-02 [PMID: 32498305] (Western Blot, Human)	Western Blot	Human
Leire Casas-Fraile, Frederique M. Cornelis, Domiziana Costamagna, Anabel Rico, Robin Duelen, Maurilio M. Sampaolesi et al. Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels Orphanet Journal of Rare Diseases 2020-12-01 [PMID: 32448375]
MB Chen, AC Yang, H Yousef, D Lee, W Chen, N Schaum, B Lehallier, SR Quake, T Wyss-Coray Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues Cell Rep, 2020-03-31;30(13):4418-4432.e4. 3/31/2020 [PMID: 32234477]
Eric Engelbrecht, Michel V Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta eLife 2020-02-24 [PMID: 32091396]
X Sun, B Wei, Z Peng, X Chen, Q Fu, C Wang, J Zhen, J Sun A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)-induced osteoporosis in rats J. Cell. Mol. Med., 2020-02-17;0(0):. 2020-02-17 [PMID: 32065504] (Rat)		Rat
Qiushi Wei, Bin Wang, Hailan Hu, Chuhai Xie, Long Ling, Jianliang Gao et al. Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression International Journal of Molecular Medicine 2020-01-20 [PMID: 31985018]
L Yin, ZX Zhou, M Shen, N Chen, F Jiang, SL Wang The Human Amniotic Mesenchymal Stem Cells (hAMSCs) Improve the Implant Osseointegration and Bone Regeneration in Maxillary Sinus Floor Elevation in Rabbits Stem Cells Int, 2019-12-11;2019(0):9845497. 2019-12-11 [PMID: 31885631] (ICC, Human)	ICC	Human
T Kazi, I Niibe, A Nishikawa, T Matsuzaki Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers FEBS Open Bio, 2019-12-28;0(0):. 2019-12-28 [PMID: 31730301] (ICC, Mouse)	ICC	Mouse
N Charoenpha, R Aeimlapa, S Sooksawanw, J Thongbunch, J Teerapornp, S Svasti, K Wongdee Responses of primary osteoblasts and osteoclasts from hemizygous beta-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D3 Sci Rep, 2019-09-27;9(1):13963. 2019-09-27 [PMID: 31562377] (ICC, Mouse)	ICC	Mouse
W Liu, L Zhang, K Xuan, C Hu, L Li, Y Zhang, F Jin, Y Jin Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3? Complex in Hypophosphatasia Theranostics, 2018-11-09;8(20):5575-5592. 2018-11-09 [PMID: 30555565] (ICC, IHC-P, Human)	ICC, IHC-P	Human
MJ Carr, JS Toma, APW Johnston, PE Steadman, SA Yuzwa, N Mahmud, PW Frankland, DR Kaplan, FD Miller Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration Cell Stem Cell, 2018-11-29;0(0):. 2018-11-29 [PMID: 30503141] (IHC, Mouse)	IHC	Mouse
RM Sterner, KN Kremer, A Dudakovic, JJ Westendorf, AJ van Wijnen, KE Hedin Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis J. Immunol., 2018-06-18;0(0):. 2018-06-18 [PMID: 29914885] (Western Blot, Mouse)	Western Blot	Mouse
G Giovannell, G Giacomazzi, H Grosemans, M Sampaolesi Morphological and functional analyses of skeletal muscles from an immunodeficient animal model of limb girdle muscular dystrophy type 2E Muscle Nerve, 2018-02-24;0(0):. 2018-02-24 [PMID: 29476695] (IHC-Fr, Mouse)	IHC-Fr	Mouse
DL Coutu, KD Kokkaliari, L Kunz, T Schroeder Multicolor quantitative confocal imaging cytometry Nat. Methods, 2017-11-13;15(1):39-46. 2017-11-13 [PMID: 29320487] (IHC, Mouse)	IHC	Mouse
M Katsuyama, M Demura, H Katsuyama, H Tanii, K Saijoh Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functions Mol Med Rep, 2017-05-25;0(0):. 5/25/2017 [PMID: 28560445]
Arjun Deb Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification Cell Stem Cell, 2016-11-17;0(0):. 2016-11-17 [PMID: 27867037] (IHC, Mouse)	IHC	Mouse
Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation Nature Communications 2016-03-07 [PMID: 26947250]
Masaki Ishikawa, Geneva L. Williams, Tomoko Ikeuchi, Kiyoshi Sakai, Satoshi Fukumoto, Yoshihiko Yamada Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns Journal of Cell Science 2016-03-01 [PMID: 26759176]
Weiqun Yu Polarized ATP distribution in urothelial mucosal and serosal space is differentially regulated by stretch and ectonucleotidases American Journal of Physiology-Renal Physiology 2015-11-15 [PMID: 26336160]
Ping-Hsing Tsai, Yueh Chien, Jen-Hua Chuang, Shih-Jie Chou, Chian-Hsu Chien, Ying-Hsiu Lai et al. Dysregulation of Mitochondrial Functions and Osteogenic Differentiation in Cisd2-Deficient Murine Induced Pluripotent Stem Cells Stem Cells and Development 2015-11-01 [PMID: 26230298]
Yoshizaki , Keigo, Hu , Lizhi, Nguyen , Thai, Sakai , Kiyoshi, He , Bing, Fong , Chak, Yamada , Yoshihik, Bikle , Daniel D, Oda , Yuko Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS ONE, 2014-06-20;9(6):e99991. 2014-06-20 [PMID: 24949995] (IHC-P, Mouse)	IHC-P	Mouse
Isaac , J, Erthal , J, Gordon , J, Duverger , O, Sun , H-W, Lichtler , A C, Stein , G S, Lian , J B, Morasso , M I DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ, 2014-06-20;21(9):1365-76. 2014-06-20 [PMID: 24948010] (IHC, Mouse)	IHC	Mouse
Liedert A, Mattausch L, Rontgen V, Blakytny R, Vogele D, Pahl M, Bindl R, Neunaber C, Schinke T, Harroch S, Amling M, Ignatius A Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading. Bone, 2010-12-23;48(4):945-51. 2010-12-23 [PMID: 21185956] (Western Blot, Mouse)	Western Blot	Mouse
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Alkaline Phosphatase/ALPL Antibody [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free AF2910-SP

Gene Symbol	ALPL
Uniprot	P09242()