Agrin Antibody

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IF/IHC, Immunohistochemistry, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-90209	Applications	Species
Melissa Ong Yu Lin, Divyaleka Sampath, Dmitriy A Bosykh, Chengchun Wang, Xiaomeng Wang, Tavintharan Subramaniam, Weiping Han, Wanjin Hong, Sayan Chakraborty YAP/TAZ Drive Agrin-Matrix Metalloproteinase-12 Mediated Diabetic Skin Wound Healing. The Journal of investigative dermatology 2024-05-27 [PMID: 38810954]
Rickelt S, Neyaz A, Condon C et al. Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker Clinical Cancer Research 2022-03-15 [PMID: 34785582] (Immunohistochemistry)	Immunohistochemistry
Chakraborty S, Sampath D, Yu Lin MO Et al. Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing Nature communications 2021-11-03 [PMID: 34732729] (IF/IHC, Human)	IF/IHC	Human
Tian C, Ohlund D, Rickelt S et al. Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma Cancer Res. 2020-02-06 [PMID: 32029550] (IF/IHC, WB, Human) Details: BxPC3 cell line	IF/IHC, WB	Human

Array NBP1-90209

• Agrin Antibodies
• Agrin ELISA Kits
• Agrin Protein
• Agrin Proteins and Enzymes