![53BP1 Antibody [Alexa Fluor 488] [NB100-304AF488]](http://images.novusbio.com/fullsize/53BP1-Antibody-Alexa-Fluor-R-488-Immunocytochemistry-Immunofluorescence-NB100-304AF488-img0008.jpg "53BP1 Antibody [Alexa Fluor 488] [NB100-304AF488]")
| Reactivity | Hu, Mu, Rt, Bt, Bv, Ca, Fi, Gt, Pm, Po, Pm, Fe, Pm-Or, Rb, ShSpecies Glossary |
| Applications | WB, ChIP, Flow, Func, ICC/IF, IHC, IP, WB, ChIP, KD, KO |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugate | Alexa Fluor 488 |
| Immunogen | Partial synthetic peptide made to an internal portion of human 53BP1 (between amino acids 350-400) [NP_005648.1]. |
| Marker | DNA Double Strand Break Marker |
| Predicted Species | Porcine (90%), Chimpanzee (96%), Rabbit (90%), Orangutan (96%), Feline (90%), Sheep (90%). Backed by our 100% Guarantee. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
| Gene | TP53BP1 |
| Purity | Immunogen affinity purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
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| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
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| Storage | Store at 4C in the dark. |
| Buffer | 50mM Sodium Borate |
| Preservative | 0.05% Sodium Azide |
| Purity | Immunogen affinity purified |
| Publication using NB100-304AF488 | Applications | Species |
|---|---|---|
| Schochter F, Werner K, KOstler C et al. 53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy-Responsive Metastatic Breast Cancer Patients Cancers (Basel) 2020-04-09 [PMID: 32283863] |
| Images | Ratings | Applications | Species | Date | Details | ||||||||
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reviewed by:
Verified Customer |
IF | Human | 07/14/2017 |
Summary
Comments
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Secondary Antibodies |
Isotype Controls |
Research Areas for 53BP1 Antibody (NB100-304AF488)Find related products by research area.
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The recent relationship of BRCA1 and 53BP1 The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage. DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m... Read full blog post. |
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53BP1 - a marker for DNA Double Strand Break 53BP1 (p53 binding protein 1) was originally thought to be an enhancer for p53 transcriptional, but later studies have demonstrated that it is actually a substrate for ataxia telangiectasia mutated (ATM). 53BP1 is a classic late DNA damage response... Read full blog post. |
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53BP1 - DNA damage is no fun The 53BP1 (p53 binding protein 1) was initially believed to be a p53 transcriptional enhancing partner, but it has now been established as an ataxia telangiectasia mutated (ATM) substrate. As a late DNA damage response (DDR) marker, 53BP1 appears duri... Read full blog post. |
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53BP1, DNA Damage Response and Tumor Suppression 53BP1 (p53 binding protein 1) was originally thought to be a p53 transcriptional enhancing partner, but now has been shown to be an ataxia telangiectasia mutated (ATM) substrate. It is a late DNA damage response (DDR) marker, appearing in the telophas... Read full blog post. |
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53BP1, DNA Damage Response and Tumor Suppression 53BP1 (p53 binding protein 1) was originally thought to be a p53 transcriptional enhancing partner, but now has been shown to be an ataxia telangiectasia mutated (ATM) substrate. It is a late DNA damage response (DDR) marker, appearing in the telophas... Read full blog post. |
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NUP153 & 53BP1: A Novel DNA Repair Pathway Mediating DNA damage is a crucial process, and one of the most important cellular guards against cancer. In response to DNA damage, sophisticated cellular machinery is recruited to repair the breaks, and if it fails, the cell is committed to death. De... Read full blog post. |
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Blocking 53BP1 Expression Lessens Tumor Development in BRCA1-Defective Mice Our antibody database at Novus Biologicals provides research tools for the forefront of cancer research. Recently, a mouse study using 53BP1 and BRCA1 antibodies showed that deletion of 53BP1 greatly lessened the incidence of tumor development in mice... Read full blog post. |
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| Gene Symbol | TP53BP1 |
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![Flow Cytometry: Rabbit IgG Isotype Control [Alexa Fluor 488] [NBP2-24982] - Intracellular analysis of TLR1 in human PBMCs (lymphocyte-gated) using this antibody. Shaded histogram represents cells alone, green represents isotype control , red represents TLR1 antibody. TLR intracellular flow kit was used for this test.](https://images.novusbio.com/images/Rabbit-IgG-Isotype-Control-[Alexa-Fluor-488]-Flow-Cytometry-NBP2-24982-img0002.jpg "Flow Cytometry: Rabbit IgG Isotype Control [Alexa Fluor 488] [NBP2-24982] - Intracellular analysis of TLR1 in human PBMCs (lymphocyte-gated) using this antibody. Shaded histogram represents cells alone, green represents isotype control , red represents TLR1 antibody. TLR intracellular flow kit was used for this test.")