Species: Hu
Applications: WB, Flow, IHC, B/N, CyTOF-ready, ELISA(Cap)
Host: Goat Polyclonal
Species: Mu
Applications: WB, Flow, CyTOF-ready
Host: Goat Polyclonal
Species: Mu
Applications: WB
Host: Rat Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Description
TGF beta Receptor II is a total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.
Bioinformatics
| Entrez |
Mouse
Mouse
Human
Rat
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
Mouse
|
| Product By Gene ID |
7048 |
| Alternate Names |
- AAT3
- EC 2.7.11
- EC 2.7.11.30
- FAA3
- HNPCC6
- LDS1B
- LDS2B
- MFS2
- RIIC
- TAAD2
- TbetaR-II
- tbetaR-II
- TGF-beta receptor type II
- TGF-beta receptor type IIB
- TGF-beta receptor type-2
- TGF-beta type II receptor
- TGFbeta-RII
- TGFR-2
- transforming growth factor beta receptor type IIC
- transforming growth factor, beta receptor II (70/80kDa) isoform 1
- transforming growth factor, beta receptor II (70/80kDa) isoform 2
- transforming growth factor, beta receptor II (70/80kDa)
- transforming growth factor, beta receptor II (70-80kD)
- Transforming growth factor-beta receptor type II
|
![Western Blot TGF-beta RII Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/TGFbeta_RII_AF241NA_Western_Blot_21284.jpg)
![Flow Cytometry TGF-beta RII Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/TGF-beta_RII_AF-241-NA_Flow_Cytometry_9958.jpg)
![Immunohistochemistry TGF-beta RII Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/TGF-beta_RII_AF-241-NA_Immunohistochemistry_9941.jpg)
![Neutralization TGF-beta RII Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/TGF-beta_RII_AF-241-NA_Block_Neutralize_8662.jpg)
![Western Blot TGF-beta RII Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/TGF-beta_RII_AF532_Western_Blot_5682.jpg)
![Flow Cytometry TGF-beta RII Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af532_mouse-tgf-beta-rii-affinity-purified-polyclonal-ab-flow-cytometry-2282024141928.jpg)
![Western Blot TGF-beta RII Antibody (129502) [Unconjugated]](http://images.novusbio.com/fullsize/mab532_mouse-tgf-beta-rii-mab-clone-129502-41202412512655.jpg)
![N/A TGF-beta RII [Biotin]](http://images.novusbio.com/fullsize2/DATA_TGFbeta_RII_DY241_ELISA_1824.jpg)
![Bioactivity TGF-beta RII [Unconjugated]](http://images.novusbio.com/fullsize/protein/241-r2cf_recombinant-human-tgf-beta-rii-protein-cf-bioactivity-141220208506.jpg)
![Bioactivity TGF-beta RII [Unconjugated]](http://images.novusbio.com/fullsize/protein/241-r2_recombinant-human-tgf-beta-rii-protein-bioactivity-1412202084741.jpg)