Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
![Western Blot Dihydrofolate Reductase/DHFR Antibody (872442) [Unconjugated]](http://images.novusbio.com/fullsize2/Dihydrofolate_Reductase_MAB7934_Western_Blot_14320.jpg)
![Immunocytochemistry Dihydrofolate Reductase/DHFR Antibody (872442) [Unconjugated]](http://images.novusbio.com/fullsize2/Dihydrofolate_Reductase_MAB7934_Immunocytochemistry_14380.jpg)
![Immunocytochemistry Dihydrofolate Reductase/DHFR Antibody (872442) [Unconjugated]](http://images.novusbio.com/fullsize2/Dihydrofolate_Reductase_MAB7934_Immunocytochemistry_14379.jpg)
![Immunohistochemistry Dihydrofolate Reductase/DHFR Antibody (872442) [Unconjugated]](http://images.novusbio.com/fullsize2/Dihydrofolate_Reductase_MAB7934_Immunohistochemistry_14259.jpg)
![Simple Western Dihydrofolate Reductase/DHFR Antibody (872442) [Unconjugated]](http://images.novusbio.com/fullsize2/Dihydrofolate_Reductase_MAB7934_Simple_Western_17256.jpg)
