DFF40/CAD Products

Description

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

Bioinformatics

Entrez	1677 Human
Uniprot	NP_004393 Human NP_004393.1 Human O76075 Human
Product By Gene ID	1677
Alternate Names	CADCaspase-activated nuclease Caspase-activated deoxyribonuclease Caspase-activated DNase CPANDNA fragmentation factor 40 kDa subunit DFF-40DFF40DFF2DNA fragmentation factor subunit beta DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) EC 3.-

Research Areas for DFF40/CAD

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Apoptosis