Myosin antibody

The Myosin superfamily is a large and diverse protein family, and its members are grouped into many classes, are involved in a number of cellular pathways (1). Myosins contain actin- and ATP-binding sites in their conserved catalytic head domain and localize to a number of intracellular compartments and participate in many trafficking and anchoring events.

Myosin is a super family of actin based molecular motors that hydrolyze ATP and generate physical force to move specific molecules inside the cell. This super family, divided into at least twenty four classes based on head domain sequence similarity and domain organization^. The processivity of myosins along an actin filament and transport of intracellular ‘cargo’ are achieved by generating physical force from chemical energy of ATP followed by appropriate conformational changes (1).

Myosin is a well-known, hexameric molecular motor that is a key cytoskeletal component. It consists of a pair of myosin heavy chain subunits (MHC), a pair of essential myosin light chain subunits (MLC), and a pair of regulatory light chain subunits (RLCs).